23RD INTERNATIONAL HERPESVIRUS WORKSHOP, YORK, ENGLAND

描述（申请人的描述）：本提案要求资金， 使年轻的研究人员能够参加第23届国际疱疹病毒 1998年8月1日至7日在英格兰约克的约克大学举办的讲习班。 的 国际疱疹病毒研讨会是首屈一指的科学会议， 疱疹病毒研究人员，和唯一的会议， 重点关注疱疹病毒的所有主要亚家族以及 从分子生物学到临床研究。 的强度 讲习班依靠的是从比较中产生的交叉施肥， 不同的疱疹病毒，不同的方法来解决关键问题， 该领域主要研究人员的支持和参与， 包括有前途的年轻研究人员和学生， 训练 此外，论坛是真正的国际性论坛，具有广泛的基础， 全球出席。 这次会议的医学重要性从广泛的 目前公认的8种人类疱疹病毒引起的各种疾病。 这些包括皮肤和眼睛溃疡（HSV-1），生殖器病变（HSV-2）， 脑膜炎和脑炎（HSV-1和HSV-2），传染性单核细胞增多症 (EBV)水痘和带状疱疹（VZV）。 巨细胞病毒是一个主要的原因出生 缺陷，包括智力迟钝、失明和耳聋， 先天性传播，但也是一种重要的机会性病原体， 艾滋病患者和器官移植接受者。 最近，CMV和HSV 已经被牵连的致病贡献者的发展， 动脉粥样硬化 癌症也与疱疹病毒有关 感染. EB病毒与伯基特淋巴瘤有关，其他B细胞 肿瘤和鼻咽癌。 最新的人类疱疹病毒 HHV-8或KSHV与艾滋病中的卡波西肉瘤有关 患者和其他免疫抑制者以及其他组。 所有 疱疹病毒终生存在，因此在 治疗免疫力低下的人。 所致疾病 大多数人类疱疹病毒的重新激活是导致 发病率和死亡率的变化。 带状疱疹和 带状疱疹后神经痛是老年人的问题。 动物疱疹[有] 对家禽（马立克氏病和其他）、猪 （伪狂犬病病毒）、牛（几种牛疱疹病毒）和马 （几种马疱疹病毒）。 此外，这些抗病毒疱疹病毒 作为研究疱疹病毒发病机制的重要模型系统。 最后， 重组DNA技术允许设计新的疫苗， 控制动物疱疹病毒感染的设计 用于基因治疗疱疹病毒载体。 讲习班将采取跨学科的办法， 主题：病毒结构，病毒进入和细胞间传播的机制， 膜蛋白，致病和潜伏，DNA复制，疫苗接种 免疫反应、转录控制、基因调控 表达、化疗靶点和病毒基因治疗。 此外，本发明还提供了一种方法， 两个命名的讲座将由个人谁作出了实质性的 对疱疹病毒学知识的贡献。

DESCRIPTION (Applicant's Description): This proposal requests funds to enable young investigators to attend the 23rd International Herpesvirus Workshop at the University of York in York, England, August 1-7, 1998. The International Herpesvirus Workshop is the premier scientific meeting for herpesvirus researchers, and the only meeting with an interdisciplinary focus on all the major subfamilies of herpes viruses and all aspects of research from molecular biology to clinical studies. The strength of the Workshop rests on the cross-fertilization that results from comparison of different herpes viruses, different approaches to key questions and on the support and participation of leading researchers in the field, most significantly including promising young investigators and students in training. Moreover, the forum is truly international, with broad-based worldwide attendance. The medical importance of this meeting is clearly indicated from the wide variety of diseases caused by the now recognized eight human herpes viruses. These include skin and eye ulcerations (HSV-1), genital lesions (HSV-2), meningitis and encephalitis (HSV-1 and HSV-2), infectious mononucleosis (EBV), chicken pox and shingles (VZV). CMV is a major cause of birth defects including mental retardation, blindness and deafness due to congenital transmission but is also a significant opportunistic pathogen in AIDS patients and organ transplant recipients. More recently, CMV and HSV have been implicated as pathogenetic contributors in the development of atherosclerosis. Cancer has also been associated with herpesvirus infections. EBV is associated with Burkitt's lymphoma, other B cell neoplasias and nasopharyngeal carcinoma. The most recent human herpesvirus discovered (HHV-8 or KSHV) is associated with Kaposi's sarcoma in AIDS patients and other immunosuppressed persons and in other groups. All of the herpes viruses persist for life and therefore pose significant problems in the treatment of immunologically compromised persons. Diseases due to reactivation of most human herpes viruses are a significant cause of morbidity and mortality in various immune patient populations. Shingles and post-herpetic neuralgia are problems in the elderly. Animal herpes [have] significant economic importance to poultry (Marek's and others), swine (pseudorabies virus), cattle (several bovine herpes viruses) and horses (several equine herpes viruses). In addition, these antiviral herpes serve as important model systems for studying herpesvirus pathogenesis. Finally, recombinant DNA technology permits the design of novel vaccines for controlling the spread of animal an herpesvirus infect the design of herpesvirus vectors for gene therapy [sic]. Workshop sessions will take an interdisciplinary approach to the following topics: virus structure, mechanism of virus entry and cell-cell spread, membrane proteins, pathogenesis and latency, DNA replication, vaccination and the immune response, transcriptional control, regulation of gene expression, chemotherapeutic targets, and virus gene therapy. In addition, two named lectures will be given by individuals who have made substantial contributions to the knowledge of herpes virology.