FERRITIN STRUCTURE/FUNCTION RELATIONSHIPS

铁蛋白结构/功能关系

• 批准号: 2679686
• 负责人: NORMAN D. CHASTEEN
• 金额: $ 1.1万
• 依托单位: UNIVERSITY OF NEW HAMPSHIRE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-14 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2679686
• 关键词: ferritin; iron metabolism; protein structure function; workshop

DESCRIPTION (adapted from the application) Ferritins store iron in a nontoxic but biologically accessible form for the synthesis of heme and limit the participation of iron in radical- producing reactions which are deleterious to cells. The complex molecular events and the structural attributes of the ferritins which enable them to carry out their function are incompletely understood. The situation is compounded by conflicting data from different laboratories, and differing views regarding the mechanisms of iron deposition and mobilization in these proteins. It is proposed to hold 2 1/2 day workshop on structure-function relationships in the ferritins, July 15-18, 1998, at Sheffield University in the U.K. Experts on ferritin, related proteins and model systems will gather to discuss their latest research, address nagging questions in the literature, define key experiments to be done and forge new collaborations. We expect that the free exchange of ideas and information will resolve many of the problems in the field, lead to a fuller understanding of structure-function relationships in ferritin, and result in a better appreciation of the central role of this important protein in iron homeostasis in humans. Funds are requested to help support the travel of foreign scientists attending the workshop.

描述（改编自应用程序） 铁蛋白以一种无毒但生物可及的形式储存铁， 血红素的合成和限制铁参与自由基- 产生对细胞有害的反应。 复杂 分子事件和铁蛋白的结构属性， 使他们能够履行其职能是不完全理解。 来自不同国家的相互矛盾的数据使情况更加复杂。 实验室，以及对铁的机制的不同看法 这些蛋白质的沉积和移动。 建议举行 2 1/2天的铁蛋白结构-功能关系研讨会， 1998年7月15日至18日，英国谢菲尔德大学。专家 铁蛋白、相关蛋白质和模型系统将聚集在一起讨论 他们的最新研究，解决了文献中令人困扰的问题， 确定要做的关键实验，并建立新的合作。 我们 我希望思想和信息的自由交流将解决许多问题。 在实地的问题，导致更全面的了解， 铁蛋白的结构-功能关系，并导致更好的 对这种重要蛋白质在铁中的核心作用的认识 人体内的稳态 请求提供资金，以帮助支持 参加研讨会的外国科学家。