CONFERENCE ON BREAST AND PROSTATE CANCER

描述：（申请人的描述）新的和令人兴奋的进展已经被 1）易患和/或 导致乳腺癌和前列腺癌，2）激素的新分子机制 作用，如描述类固醇受体辅助调节剂， 新类固醇受体、类固醇激素受体的鉴定 与膜启动的信号转导途径的相互作用，3） 环境激素模拟物和新机制的鉴定 它们可能影响正常和癌变乳腺的生长和功能 和前列腺 由于正常乳腺和前列腺的生长和功能都是激素的作用 依赖性和它们各自的癌症是激素反应性的， 激素的作用和作用机制对于 癌症病因学、预防和治疗。 乳腺癌和前列腺癌 有许多共同的特点：它们是最常见的诊断癌症， 美国女性和男性，分别;都是由性类固醇调节; 两者都发展激素独立性;两者都有遗传成分;两者都 器官具有小管肺泡结构;并且对于这两个器官， 基质-上皮相互作用在组织中起重要作用 形态发生和生长控制。 Keystone的目标是 乳腺癌和前列腺癌研讨会是提供一个多学科的 该计划解决了关键问题，并提供了有关以下方面的新信息： 1)内源性激素/生长因子的作用机制是什么 以及外源性激素（激素替代疗法和/或 环境激素）在癌症病因和进展中的作用2）什么是 激素和基因突变在致癌作用中的相互作用以及3）如何 这些知识能否被用来开发治疗癌症的新策略 预防和治疗。 人们希望分享的知识和想法 将确定未来努力的新方向， 将前列腺和乳腺研究人员聚集在一起， 对乳腺癌和前列腺癌的协同作用。

DESCRIPTION: (Applicant's Description) New and exciting advances have been made in the delineation of 1) genetic alterations which predispose to and/or cause breast and prostate cancer, 2) novel molecular mechanisms of hormone action, such as delineation of steroid receptor co-regulators, identification of novel steroid receptors, steroid hormone receptor interactions with membrane initiated signal transduction pathways, 3) identification of environmental hormone mimetics and novel mechanisms by which they may impact on growth and function of normal and cancerous breast and prostate. Since the growth and function of both normal breast and prostate are hormone dependent and their respective cancers are hormone responsive, delineating the roles and mechanisms of action of hormones is pivotal for progress in cancer etiology, prevention and therapy. Breast cancer and prostate cancer share many features: they are the most commonly diagnosed cancers in American women and men, respectively; both are regulated by sex steroids; both develop hormone independence; both have a hereditary component; both organs have a tubuloalveolar architecture; and for both organs, stromal-epithelial interactions play an important role in tissue morphogenesis and growth control. The goal of the proposed Keystone Symposium on Breast and Prostate Cancer is to provide a multidisciplinary program that addresses key questions and presents novel information about: 1) what are the mechanisms of action of endogenous hormones/growth factors and the role of exogenous hormones (hormone replacement therapy and/or environmental hormones) in etiology and progression of cancer 2) what is the interaction between hormones and gene mutations in carcinogenesis and 3) how can this knowledge be exploited to develop novel strategies for cancer prevention and therapy. It is expected that the knowledge shared and ideas generated will identify new directions for future endeavors and that bringing together researchers working on prostate and breast will have a synergistic impact on breast and prostate cancer.