ETHANOL AND PENTOBARBITAL SELF ADMINISTRATION IN RATS

乙醇经常与其他药物一起滥用，因此研究 检查乙醇的自我给药与其他药物的结合 药物可能有助于发展动物模型，可以评估 行为和药物治疗的疗效旨在 减少多药滥用者的酒精饮用量。这项建议是 由三项相关研究组成。每项研究都是为了评估 乙醇单独增强AS的作用的一个单独方面 以及乙醇和另一种滥用药物的结合。在第一个 研究将训练大鼠口服自我给药的组合 乙醇和戊巴比妥钠后的增强性能 将对乙醇和药物混合物进行评估。这将是 通过检查 乙醇/戊巴比妥混合物的数量与乙醇的比较 在一定范围内单独使用并发自我管理程序 固定比率的值。该系列的第二项研究建议 检测纳曲酮对乙醇自我给药的影响 还有乙醇和戊巴比妥的混合物。这项研究将使用 乙醇和乙醇+戊巴比妥钠的新型多重方案 自我给药序贯评价纳曲酮对血管紧张素转换酶的影响 在一次测试中同时对乙醇和混合物做出反应 会议。第三项研究将使用乙醇褪色程序来 尝试训练大鼠自行口服戊巴比妥。如果 如果成功，这个训练过程可能会被证明是有效的 大鼠也可以自行口服其他滥用药物。它是 希望这些研究将产生对行为的洞察力 乙醇和多药自身的神经化学参数 行政管理。

Ethanol is frequently co-abused with other drugs, therefore studies examining self-administration of ethanol in combination with other drugs may help develop animal models which can assess the efficacy of behavioral and pharmacological treatments designed to reduce ethanol drinking in polydrug abusers. This proposal is comprised of three related studies. Each study is designed to asses an individual aspect of the reinforcing effects of ethanol alone as well as ethanol combined with another drug of abuse. In the first study rats will be trained to orally self-administer a combination of ethanol and pentobarbital after which the reinforcing properties of ethanol and the drug mixture will be assessed. This will be accomplished by examining the relative reinforcing effects of a number of ethanol/pentobarbital combinations compared to ethanol alone using concurrent self-administration procedures over a range of fixed-ratio values. The second study in the series proposes to examine the effects of naltrexone on self-administration of ethanol and an ethanol plus pentobarbital mixture. This study will use a novel multiple schedule of ethanol and ethanol plus pentobarbital self-administration to sequentially assess the effects of naltrexone on responding for both ethanol and the mixture within a single test session. The third study will use an ethanol fading procedure to attempt to train rats to orally self-administer pentobarbital. If successful, this training procedure may prove effective at inducing rats to orally self-administer other drugs of abuse as well. It is hoped that these studies will produce insights into the behavioral and neurochemical parameters of ethanol and polydrug self- administration.