MECHANISMS OF REPAIR OF ISCHEMIC INJURED INTESTINE
缺血性损伤肠的修复机制
基本信息
- 批准号:2668278
- 负责人:
- 金额:$ 3.6万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1998
- 资助国家:美国
- 起止时间:1998-02-08 至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
The goal of this laboratory is to identify mechanisms of intestinal repair
in order to facilitate recovery of injured intestine. Intestinal ischemial
reperfusion injury is of particular interest because of its role in the
equine colic syndrome, the principal killer of horses. A model of
ischemia/ reperfusion injury will be developed in the pig. It is possible
that the pig will provide a better model for the human and the horse,
because of similar low levels of xanthine oxidase. The relative
contribution of ischemia and reperfusion to intestinal injury will be
determined. Ischemic injury appears to he more important in large animal
species than reperfusion injury, as opposed to rodent models in which
reperfusion injury is prominent. Because of a failure to block reperfusion
injury in the horse, and the questionable relevance of rodent models of
reperfusion injury to the human, the repair process will be characterized.
The ability of glutamine (GLN) and growth factors to enhance proliferation
will be investigated, and the mechanism by which GLN facilitates repair
will he examined. Specifically, activation of Jun-nuclear kinase and
Mitogen-activated kinase, enzymes critical for the induction of "early-
immediate" genes, will be assessed. These studies should provide basic
information on mechanisms of epithelial proliferation and alternative
therapeutic approaches to ischemic injury.
这个实验室的目标是确定肠道修复的机制
以促进受损肠的恢复。肠缺血
再灌注损伤是特别感兴趣的,因为它在脑缺血中的作用。
马绞痛综合症,马的主要杀手。的典范
将在猪中产生缺血/再灌注损伤。可以
猪将为人类和马提供一个更好的模型,
因为黄嘌呤氧化酶的水平也很低。的相对
缺血和再灌注对肠损伤的贡献将是
测定缺血性损伤在大型动物中显得更为重要
物种比再灌注损伤,而不是啮齿动物模型,其中
再灌注损伤显著。由于未能阻断再灌注
马的伤害,以及啮齿动物模型的可疑相关性,
再灌注损伤的人,修复过程的特点。
谷氨酰胺(GLN)和生长因子促进增殖的能力
将被调查,GLN促进修复的机制
他将检查。具体而言,Jun-nuclear kinase和
丝裂原活化激酶,对诱导“早期-
将评估“立即”基因。这些研究提供了基本的
关于上皮细胞增殖机制和替代方法的信息
缺血性损伤的治疗方法。
项目成果
期刊论文数量(7)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Mechanisms of intestinal mucosal repair.
肠粘膜修复机制。
- DOI:
- 发表时间:1997
- 期刊:
- 影响因子:0
- 作者:Blikslager,AT;Roberts,MC
- 通讯作者:Roberts,MC
How important is intestinal reperfusion injury in horses?
马的肠道再灌注损伤有多重要?
- DOI:
- 发表时间:1997
- 期刊:
- 影响因子:0
- 作者:Blikslager,AT;Roberts,MC;Gerard,MP;Argenzio,RA
- 通讯作者:Argenzio,RA
Peptide YY inhibits intestinal Cl- secretion in experimental porcine cryptosporidiosis through a prostaglandin-activated neural pathway.
肽 YY 通过前列腺素激活的神经通路抑制实验性猪隐孢子虫病的肠道 Cl 分泌。
- DOI:
- 发表时间:1997
- 期刊:
- 影响因子:0
- 作者:Argenzio,RA;Armstrong,M;Blikslager,A;Rhoads,JM
- 通讯作者:Rhoads,JM
Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?
- DOI:10.1016/s0039-6060(97)90107-0
- 发表时间:1997-05-01
- 期刊:
- 影响因子:3.8
- 作者:Blikslager, AT;Roberts, MC;Argenzio, RA
- 通讯作者:Argenzio, RA
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ANTHONY BLIKSLAGER其他文献
ANTHONY BLIKSLAGER的其他文献
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{{ truncateString('ANTHONY BLIKSLAGER', 18)}}的其他基金
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine
肠胶质细胞-上皮相互作用在缺血性损伤肠道修复中的出生后发育
- 批准号:
10655459 - 财政年份:2019
- 资助金额:
$ 3.6万 - 项目类别:
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine
肠胶质细胞-上皮相互作用在缺血性损伤肠道修复中的出生后发育
- 批准号:
10179436 - 财政年份:2019
- 资助金额:
$ 3.6万 - 项目类别:
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine
肠胶质细胞-上皮相互作用在缺血性损伤肠道修复中的出生后发育
- 批准号:
9794929 - 财政年份:2019
- 资助金额:
$ 3.6万 - 项目类别:
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine
肠胶质细胞-上皮相互作用在缺血性损伤肠道修复中的出生后发育
- 批准号:
10437688 - 财政年份:2019
- 资助金额:
$ 3.6万 - 项目类别:
Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
新型 NF-kB 抑制剂在炎症性肠病中的验证
- 批准号:
8502651 - 财政年份:2006
- 资助金额:
$ 3.6万 - 项目类别:
MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
前列腺素诱导的肠道修复机制
- 批准号:
6178059 - 财政年份:1998
- 资助金额:
$ 3.6万 - 项目类别:
MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
前列腺素诱导的肠道修复机制
- 批准号:
2849617 - 财政年份:1998
- 资助金额:
$ 3.6万 - 项目类别:
MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
前列腺素诱导的肠道修复机制
- 批准号:
6523696 - 财政年份:1998
- 资助金额:
$ 3.6万 - 项目类别:
MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
前列腺素诱导的肠道修复机制
- 批准号:
6381058 - 财政年份:1998
- 资助金额:
$ 3.6万 - 项目类别:
MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
前列腺素诱导的肠道修复机制
- 批准号:
2906135 - 财政年份:1998
- 资助金额:
$ 3.6万 - 项目类别: