NEURAL BASIS OF VASCULAR HEAD PAIN

血管性头痛综合征如偏头痛是最常见的 所有的医疗问题。 然而，血管性头痛的神经基础是 知之甚少且极具争议 的研究现状 血管性头痛的机制集中在疼痛的作用上， 颅内血管的敏感感觉神经支配， 三叉神经 进一步了解这种感觉的作用 血管性头痛的神经通路受到我们知识的关键空白的限制 这些通路的特性，特别是与它的感觉， 功能和伤害性信息的传递。 为了 更好地了解血管性头痛的外周机制， 拟议的研究将表征初级的生理特性， 神经传入神经元支配的主要血管的 颅内硬脑膜 将使用单个单元记录来研究 分级时硬脑膜初级传入神经元的放电活动 机械、热和化学血管刺激 大鼠 将进行重复刺激范例以调查 由不同形式的血管刺激诱导的致敏。 的 这些研究所提供的信息将是进一步的关键， 了解血管性头痛的神经基础的进展。

Vascular headache syndromes such as migraine are among the most common of all medical problems. However, the neural basis of vascular headache is poorly understood and highly controversial. Current research on the mechanisms of vascular headache has focused on the role of a pain- sensitive sensory innervation of cranial blood vessels that arises from the trigeminal nerve. Further understanding of the role of this sensory pathway in vascular head pain is limited by critical gaps in our knowledge of those properties of the pathway that relate specifically to its sensory function and the transmission of nociceptive information. In order to better understand the peripheral mechanisms of vascular head pain, the proposed studies will characterize the physiological properties of primary afferent neurons that innervate the major blood vessels of the intracranial dura. Single-unit recording will be used to study the discharge activity of dural primary afferent neurons during graded mechanical, thermal, and chemical vascular stimulation in anesthetized rats. Repeated stimulation paradigms will be carried out to investigate sensitization induced by different forms of vascular stimulation. The information provided by these studies will be critical for further progress in understanding the neural basis of vascular head pain.