MICROINJECTION INSTRUMENT FOR BRAIN CELL IMPLANTATION

描述：调查人员计划开发一种设备，用于 立体定向植入细胞或微量注射药物或 营养因子到大脑深处的位置。而其他喷射系统 这个系统已经存在，在几个方面都是独一无二的。初级阶段 不同的是注射插管部分的直径 设备。该装置还将允许以与主要部件成一定角度的方式投放 并可用于电生理记录，如 井。 建议的商业应用： 建议的设备将作为可重复使用的设备出售给神经外科医生 立体定位载体和一次性微注射针头。如果是这样的话 最初主要用于帕金森氏症，以制造细胞 注射，后来用于神经外科手术的其他疾病 准确地在脑内放置一组小容量注射将具有 治疗效果。

DESCRIPTION: The investigators plan to develop a device for stereotaxically implanting cells or microinjection of pharmacologic or trophic factors to deep brain sites. While other injection systems already exist, this system would be unique in several ways. The primary difference is the diameter of the injection cannula portion of the device. The device would also allow delivery at an angle to the primary cannula tract and could be used for electrophysiological recordings as well. PROPOSED COMMERCIAL APPLICATION: The proposed device would be sold to neurosurgeons as a reuseable stereotaxic carrier and a disposable microinjector needle. It would be used initially primarily for Parkinson's disease to make cell injections, and later for neurosurgery for other diseases where an accurately place set of small volume injections in brain would have therapeutic effect.