CHRONIC TELEMETRY OF INTRACRANIAL PRESSURE

在脑肿胀的治疗中，脑灌注压(CPP)是一种 临界参数定义为平均动脉血与平均动脉血 血压和颅内压(ICP)。而平均动脉血 可常规监测压力，安全、准确、廉价、 需要可靠、小型、可植入的压力遥测单元来 定期监测颅内压。 一种集成电路，可长期植入温度和压力 提出了满足这些标准的遥测单元。功率和 数据遥测将安装在皮下颅骨螺栓上，带有一个 安装在底部或实质内探头上的压力传感器。 在体外测试后，硬膜外、硬膜下和实质内 传感器将植入四只动物体内。遥测输出将是 与3个月的标准读数进行比较，以评估稳定性和 哺乳动物大脑的准确性。 潜在的遥测ICP候选对象包括有头部疾病的患者 外伤、脑肿瘤、大脑假瘤、脑内和蛛网膜下腔 出血、脑积水、神经外科术后脑肿胀、雷伊氏病 综合症、脑感染和中毒性/代谢性脑病。 门诊用途可能包括检测患者的脑肿胀 接受肿瘤放射治疗，或从头部创伤中恢复 监测脑积水。 第二阶段将专注于长期测试、制造问题、 临床试验，并纳入更多的传感模式。 建议的商业应用： 如果成功，拟议的遥测仪将提供安全、准确、 一种廉价、可靠、小巧的颅内压读数装置 和温度。它将用于急诊和重症监护 颅脑创伤及多发伤患者的颅内压监测 其他条件。遥测仪也可以作为一种慢性的 用于脑积水或其他慢性疾病的家庭监测的植入式设备 可能导致颅内压过高的情况。

In treatment of brain swelling, cerebral perfusion pressure (CPP) is a critical parameter defined as the difference between mean arterial blood pressure and intracranial pressure (ICP). While mean arterial blood pressure can be routinely monitored, a safe, accurate, inexpensive, reliable, small, implantable pressure telemetry unit is needed to routinely monitor ICP. An integrated circuit, chronically implantable temperature and pressure telemetry unit that will satisfy these criteria is proposed. Power and data telemetry will be mounted on a subcutaneous cranial bolt with a pressure sensor mounted on the bottom or on an intraparenchymal probe. Following in-vitro testing, epidural, subdural and intraparenchymal sensors will be implanted in four animals. Telemetered outputs will be compared with standard readings for 3 months to assess stability and accuracy in mammalian brain. Potential candidates for telemetered ICP include patients with head trauma, brain tumor, pseudotumor cerebri, intracerebral and subarachnoid hemorrhage, hydrocephalus, neurosurgical postop brain swelling, Reye's syndrome, brain infections and toxic/metabolic encephalopathies. Outpatient uses may include detection of brain swelling in patients undergoing radiation therapy for tumors, or recovering from head trauma and monitoring hydrocephalus. Phase II will focus on longer term testing, manufacturing issues, clinical trials, and incorporation of additional sensing modalities. PROPOSED COMMERCIAL APPLICATIONS: If successful, the proposed telemeters will provide a safe, accurate, inexpensive, reliable, small device for readout of intracranial pressure and temperature. It will be marketed for emergency and intensive care monitoring of intracranial pressure in cases of head trauma and many other conditions. The telemeters may also be marketed as a chronically implantable device for home monitoring for hydrocephalus or other chronic conditions that may result in excessive intracranial pressure.