BIODEGRADABLE GUIDES FOR PERIPHERAL NERVE REGENERATION

描述(改编自申请者摘要)：周围神经 损害是创伤性人身伤害和疾病的常见结果。 受压的甚至切断的周围神经一般都会 再生，然而，有时组织的损失太大， 实用的端到端缝合，以重新连接神经节段。当这是 不可能，恢复后仍可重新生成这两个数据段 如果合适的管道或神经导引将切断的末端连接起来，就能发挥作用。 使用聚乳酸-乙交酯共聚物(PLGA)的小微球，Biotek 使用了一种称为SNS(溶剂-非溶剂)的物理化学方法 制备10 mm长的带有内侧的神经导向器的工艺 直径1.3毫米，壁厚0.85毫米。这些指南，其中 足够疏松，可以让水通过墙壁流动，足够坚固 以抵抗10公斤/毫米的破碎力。建议研究一下 微珠尺寸、壁厚和工艺参数对In的影响 体外神经引导特性，包括强度、水通量速率 穿过墙，以及缓冲器中的强度损失率。三根神经 将使用组织学检查和 函数返回标准，用于促进 大鼠坐骨神经移植后的再生。 建议的商业应用：不可用。

DESCRIPTION (Adapted from Applicant's Abstract): Peripheral nerve damage is a common result of traumatic personal injuries and of disease. Crushed or even severed peripheral nerves are generally amenable to regeneration, however at times the loss of tissue is too great for practical end-to-end suturing to rejoin nerve segments. When this is not possible, the two segments can still be regenerated with restoration of function if suitable conduit, or nerve guide, joins the severed ends. Employing small microbeads of polylactide-co-glycolide (PLGA), BIOTEK has used a physicochemical method called SNS (solvent-non-solvent) processing to prepare nerve guides which are 10 mm long with an inner diameter of 1.3 mm and a wall thickness of 0.85 mm. these guides, which porous enough to allow water to flow through the walls, ar strong enough to resist a crushing force of 10 kg/mm. It is proposed to study the effect of microbead size, wall thickness, and process parameters on in vitro nerve guide properties, including strength, rates of water flux through the wall, and rate of strength loss in buffer. Three nerve guide types will be evaluated, using both histological examination and return of function criteria, for efficacy in facilitating the regeneration of the transacted rat sciatic nerve. PROPOSED COMMERCIAL APPLICATION: Not available.