BIODEGRADABLE GUIDES FOR PERIPHERAL NERVE REGENERATION

可生物降解的周围神经再生指南

• 批准号: 2650996
• 负责人: ELIE NUWAYSER
• 金额: $ 10万
• 依托单位: BIOTEK, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2650996
• 关键词: biomedical equipment development; clinical biomedical equipment; histology; laboratory rat; method development; nervous system regeneration; polymers

DESCRIPTION (Adapted from Applicant's Abstract): Peripheral nerve damage is a common result of traumatic personal injuries and of disease. Crushed or even severed peripheral nerves are generally amenable to regeneration, however at times the loss of tissue is too great for practical end-to-end suturing to rejoin nerve segments. When this is not possible, the two segments can still be regenerated with restoration of function if suitable conduit, or nerve guide, joins the severed ends. Employing small microbeads of polylactide-co-glycolide (PLGA), BIOTEK has used a physicochemical method called SNS (solvent-non-solvent) processing to prepare nerve guides which are 10 mm long with an inner diameter of 1.3 mm and a wall thickness of 0.85 mm. these guides, which porous enough to allow water to flow through the walls, ar strong enough to resist a crushing force of 10 kg/mm. It is proposed to study the effect of microbead size, wall thickness, and process parameters on in vitro nerve guide properties, including strength, rates of water flux through the wall, and rate of strength loss in buffer. Three nerve guide types will be evaluated, using both histological examination and return of function criteria, for efficacy in facilitating the regeneration of the transacted rat sciatic nerve. PROPOSED COMMERCIAL APPLICATION: Not available.

描述（改编自申请人的摘要）：外周神经 损害是创伤性人身伤害和疾病的常见结果。 被压碎甚至切断的周围神经一般都能接受 再生，然而，有时组织的损失太大， 实用的端对端缝合来重新连接神经节段。 等这事 不可能，这两个段仍然可以通过恢复重新生成 如果合适的导管或神经导管连接切断的末端， 采用聚乳酸-共-乙交酯（PLGA）小微珠，BIOTEK 使用了一种称为SNS（溶剂-非溶剂）的物理化学方法， 处理以制备10 mm长的神经导管， 直径为1.3 mm，壁厚为0.85 mm。这些导向器 多孔的足以让水流过墙壁，足够坚固， 以抵抗10 kg/mm的破碎力。建议研究 微珠尺寸、壁厚和工艺参数对In的影响 体外神经导丝性能，包括强度、水通量率 缓冲层的强度损失率。 三神经 将使用组织学检查和 功能恢复标准，以促进 大鼠坐骨神经的再生。 拟议的商业应用：不可用。