MULTICHANNEL SAMPLING SYSTEM FOR FREELY MOVING ANIMALS

适用于自由移动动物的多通道采样系统

• 批准号: 2537549
• 负责人: ROBERT W. BONSALL
• 金额: $ 9.99万
• 依托单位: CIRCULAR SOLUTIONS, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-15 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2537549
• 关键词: biomedical automation; biomedical equipment development; circadian rhythms; corticosterone; data collection; electrophysiology; ethology; laboratory rat; microdialysis; serology /serodiagnosis; stress; telemetry

A novel multichannel system called the Sample Collection Turntable (SCT) has been developed for studies of freely-moving laboratory animals. It substantially increases both the amount and quality of information obtainable from animal studies, and it will cost significantly less than currently available, less effective, alternatives. The SCT was designed to provide a stress-free environment for the animals under study. In Phase I of this project, behavioral and physiological measures that are sensitive to chronic stress will be used to determine if this goals has been reached. Preliminary testing has been performed on the SCT in a configuration that makes seven independent fluid connections with the animal: this is not possible with systems that rely on fluid swivels. Samples are collected and stored automatically in a unique device that is capable of unattended operation over periods of several days, and drugs and hormones are delivered automatically without subjecting the animal to the stress of handling and injections. By enabling more information to be obtained from each animal, the SCT can help reduce the overall number of animals needed, in accord with NIH directives. The SCT has additional potential for combining methods such as microdialysis electrophysiology, cyclic voltammetry or automated blood sampling. PROPOSED COMMERCIAL APPLICATION Academic research in Neuroscience, Physiology, Pharmacology and the Behavioral Sciences; R&D of new drugs. The SCT also opens up the possibility of improved and cost effective methods for commercial testing of foodstuffs and pharmaceuticals.

一种新型的多通道系统，称为样品收集转盘（SCT） 是为研究自由移动的实验室动物而开发的。 它 大大提高了信息的数量和质量 从动物研究中获得，它的成本将大大低于 目前可用的、效果较差的替代品。 SCT的设计 为研究中的动物提供无压力的环境。 在 这个项目的第一阶段，行为和生理措施， 对慢性压力的敏感性将被用来确定这一目标是否具有 已经到达。 已在一个环境中对SCT进行了初步测试， 配置，使七个独立的流体连接， 动物：这对于依赖于流体转环的系统是不可能的。 样本被自动收集并储存在一个独特的设备中， 能够在数天内无人值守运行，并且 药物和激素是自动输送的， 动物对处理和注射的压力。 通过启用更多 从每只动物身上获得的信息，SCT可以帮助减少 所需动物总数，符合NIH指令的雅阁。的SCT 具有将微透析等方法结合起来的额外潜力， 电生理学、循环伏安法或自动血液取样。 建议的商业应用 在神经科学、生理学、药理学和 行为科学;新药研发。 SCT还打开了 改进和成本效益高的商业方法的可能性 食品和药品的测试。