NONINVASIVE PHOTOACOUSTIC INTRACRANIAL PRESSURE MONITOR

这项建议是为了开发一种新型的光声传感器，用于 无创连续监测颅内压(ICP) 有头部或脑损伤的患者。该技术可用于测量颅内压 更改为优于0.5毫米汞的精度，提供了重要的 脑生理参数用于诊断、临床评估和 在急诊现场、医院和家中护理病人。颅内压监测是 通过高分辨率(15微米)的移位检测实现 通过测量蛛网膜下腔内的血管层 光声信号的传输时间。此信号由以下方式生成 通过吸收伪随机的组织的热应力 调制(PRM)近红外照明。该传感器采用SESI的 专有PRM和分辨率增强技术，实现高性能 分辨率和连续测量而不使组织受制于 辐射损伤。在第一阶段进行可行性研究后，使用 脑组织和血管模型，一个坚固耐用的便携式原型 将在第二阶段开发，与 一个医学研究小组。传感器将与其他设备集成在一起 用于检测局部颅内压升高的无创诊断技术， 脑部血肿或水肿。 建议的商业应用： 该传感器的商业应用非常有前景。它可以用来 急诊室、急诊室、重症监护室、生理科 用于颅内压监测、血液监测的研究和临床患者管理 血氧饱和度和脑部诊断。

This proposal is to develop a novel photoacoustic sensor for the noninvasive and continuous monitoring of the intracranial pressure (ICP) of patients with head or brain injury. The technique can measure the ICP changes to an accuracy of better than 0.5 mmHg, providing an important cerebral physiological parameter for diagnosis, clinical assessment and care of patient at emergency site, hospital and home. ICP monitoring is achieved through the high resolution (15 microM) detection of the shift of the blood vessel layer in the subarachnoid space by measuring the transit time of the photoacoustic signal. This signal is generated by the thermal stress of tissue through the absorption of a pseudo-random modulated (PRM) near IR illumination. The sensor employs SESI's proprietary PRM and resolution enhancement technique to achieve high resolution and continuous measurement without subjecting the tissue to radiation damage. Following the feasibility study in Phase I using a brain tissue and blood vessel phantom, a rugged and portable prototype will be developed in Phase II for clinical test in collaboration with a medical research group. The sensor will be integrated with other noninvasive diagnostic techniques for detection of local ICP elevation, brain hematoma or edema. PROPOSED COMMERCIAL APPLICATION: Commercial applications for the sensor is very promising. It can be used at emergency site, emergency unit, intensive care unit, physiological studies, and clinical patient management for ICP monitoring, blood oximetry and cerebral diagnosis.