POLYMER MATRICES FOR ARTICULAR CARTILAGE REGENERATION

描述(改编自申请人的摘要)：发展和 用于软骨修复的细胞外基质的商业化 将对生活质量和经济有很大好处 世界各地的医疗保健。这个第二阶段提案的长期目标是 是开发一种支持原位迁移的聚合物基质 具有关节修复能力的软骨祖干细胞 软骨缺陷症。胶原蛋白多糖的一种制备方法 矩阵是在项目的第一阶段开发的，结果是 据报道，基质既支持成骨又支持软骨生成。 在之前成功的基础上，调查人员计划优化和 在第二阶段研究中提炼它们的胶原基基质。可注射的 或关节镜下植入的基质或浸渍有 将测试成软骨生长因子的整合能力 在牛和羊的软骨外植体培养中加入宿主组织。这些 还将使用四种活体动物模型(大鼠， 兔子、狗和马)。研究人员计划评估植入 并对材料的力学性能进行了分析。 修复组织。生物相容基质的可用性 促进自体祖细胞的迁移和分化 干细胞转化为功能性软骨细胞提供了一种新颖、经济高效的方法 修复受损软骨组织的技术。 建议的商业应用：不可用

DESCRIPTION (Adapted from the applicant's abstract): The development and commercialization of extracellular matrix for use in cartilage repair will be of major benefit to the quality of life and to the economics of health care worldwide. The long term objective of this Phase II proposal is to develop a polymer matrix that supports the in situ migration of chondrogenic progenitor stem cells capable of repairing articular cartilage defects. A method of fabricating collagen-proteoglycan matrices was developed in Phase I of the project and the resulting matrices were reported to support both osteogenesis and chondrogenesis. Based on their earlier success, the investigators plan to optimize and refine their collagen based matrices in the Phase II study. Injectible or arthroscopically implantable matrix or matrix impregnated with chondrogenic growth factor will be tested for its ability to integrate with host tissue in cow and sheep cartilage explant cultures. These matrices will also be evaluated using four in vivo animal models (rat, rabbit, dog and horse). The investigators plan to assess implantation of the matrix by athroscopy and to analyze the mechanical properties of the repair tissue. Availability of biocompatible matrices that would facilitate migration and differentiation of autologous progenitor cells stem cells into functional chondrocytes provides a novel, cost-effective technique for restoration and repair of damaged cartilage tissue. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE