POLYMER MATRICES FOR ARTICULAR CARTILAGE REGENERATION

用于关节软骨再生的聚合物基质

• 批准号: 2649739
• 负责人: ROBERT C. SPIRO
• 金额: $ 37.5万
• 依托单位: ORQUEST, INC.
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-26 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2649739
• 关键词: articular cartilage; biomaterial development /preparation; biomaterial evaluation; cartilage development; collagen; dogs; extracellular matrix; horses; implant; laboratory rabbit; laboratory rat; mucopolysaccharides; orthopedics; osteogenesis; polymers; proteoglycan; tissue support frame

DESCRIPTION (Adapted from the applicant's abstract): The development and commercialization of extracellular matrix for use in cartilage repair will be of major benefit to the quality of life and to the economics of health care worldwide. The long term objective of this Phase II proposal is to develop a polymer matrix that supports the in situ migration of chondrogenic progenitor stem cells capable of repairing articular cartilage defects. A method of fabricating collagen-proteoglycan matrices was developed in Phase I of the project and the resulting matrices were reported to support both osteogenesis and chondrogenesis. Based on their earlier success, the investigators plan to optimize and refine their collagen based matrices in the Phase II study. Injectible or arthroscopically implantable matrix or matrix impregnated with chondrogenic growth factor will be tested for its ability to integrate with host tissue in cow and sheep cartilage explant cultures. These matrices will also be evaluated using four in vivo animal models (rat, rabbit, dog and horse). The investigators plan to assess implantation of the matrix by athroscopy and to analyze the mechanical properties of the repair tissue. Availability of biocompatible matrices that would facilitate migration and differentiation of autologous progenitor cells stem cells into functional chondrocytes provides a novel, cost-effective technique for restoration and repair of damaged cartilage tissue. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自申请人的摘要）：开发和 用于软骨修复的细胞外基质的商业化 将对生活质量和经济产生重大影响。 全世界的医疗保健。本第二阶段提案的长期目标 是开发一种聚合物基质， 具有修复关节功能的软骨祖细胞 软骨缺损一种制备胶原蛋白聚糖的方法， 矩阵是在项目的第一阶段开发的， 据报道基质支持骨生成和软骨生成。 基于他们早期的成功，研究人员计划优化和 在第二阶段研究中精制其胶原蛋白基质。可注射 或关节镜下可植入的基质或浸渍有 将测试软骨生长因子整合 与牛和羊软骨外植体培养物中的宿主组织。这些 还将使用四种体内动物模型（大鼠， 兔子、狗和马）。研究人员计划评估植入 并对复合材料的力学性能进行了分析 修复组织生物相容性基质的可用性， 促进自体祖细胞的迁移和分化 将干细胞转化为功能性软骨细胞提供了一种新的、具有成本效益的 修复受损软骨组织技术。 拟议商业应用：不可用