Links between DNA replication and chromosome end maintenance

DNA复制和染色体末端维持之间的联系

• 批准号: DP190103572
• 负责人: Prof Tracy Bryan
• 金额: $ 39.96万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103572
• 关键词: Links; between; DNA; replication; chromosome

This project aims to increase knowledge of the way in which cells maintain their genomes, including the ends of their chromosomes, to enable their own survival. The ends of chromosomes (telomeres) are essential for survival and proliferation of the cells of most organisms. This project aims to determine the molecular details of a recently discovered link between telomere maintenance and the way cells maintain the integrity of their genome. This is likely to lead to increased understanding of the fundamental biological process of genome maintenance, representing a significant scientific advance. The project expects to have far-reaching implications for biotechnology applications that require the survival of cells.

该项目旨在增加对细胞维持基因组的方式的了解，包括染色体的末端，以使自己能够生存。染色体(端粒)的末端对于大多数生物细胞的生存和增殖是必不可少的。该项目旨在确定最近发现的端粒维持与细胞维持基因组完整性之间的联系的分子细节。这可能会增加对基因组维持的基本生物学过程的理解，这是一项重大的科学进步。该项目预计将对需要细胞生存的生物技术应用产生深远的影响。