FIBRIN COMPOSITES FOR GAPING CUTANEOUS WOUNDS

用于裂开皮肤伤口的纤维蛋白复合材料

• 批准号: 2536439
• 负责人: RICHARD August CLARK
• 金额: $ 10万
• 依托单位: V. I. TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2536439
• 关键词: biomaterial development /preparation; biotechnology; cell migration; extracellular matrix; fibrin; fibroblasts; growth factor; hemostasis; tissue engineering; tissue support frame; wound healing

DESCRIPTION: (Adapted from the Applicant's Abstract): The formation of a fibrin clot enriched with extracellular matrix material and growth factors is important for recruiting cells to a wound site. The aim of this phase 1 proposal is to develop a hemostatically functional fibrin composite that facilitates cell recruitment to a site of injury. This material would be useful in clinical settings in which both optimal hemostasis and rapid formation of new tissue are needed, including both acute wounds and debrided chronic cutaneous ulcers. The applicant organization has designed a novel fibrin matrix composite that markedly enhances cell recruitment. An in vitro assay for cell migration across three-dimensional extracellular matrix boundaries will be used in order to define and characterize further the essential components of this cell recruitment material. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述：(改编自申请人摘要)：形成 富含细胞外基质和生长的纤维蛋白凝块 因子对于将细胞招募到伤口部位很重要。的目的是 这一阶段的建议是开发一种具有止血功能的纤维蛋白。 促进细胞向损伤部位募集的复合材料。这 材料在临床环境中将是有用的，在这种环境中，既有最佳的 止血和迅速形成新的组织是必要的，包括这两者 急性伤口和清创的慢性皮肤溃疡。申请人 该组织设计了一种新型纤维蛋白基质复合材料，显著 增强细胞招募。一种细胞跨膜迁移的体外检测方法 将使用三维细胞外基质边界来 进一步定义和描述该细胞的基本成分 招聘材料。 建议的商业应用：不可用