MUTAGENICITY TESTING IN SALMONELLA

该合同的目标是测试大约25个 每年使用体外沙门氏菌进行致突变性的化学品 致突变试验沙门氏菌检测已被广泛接受 作为一种化学品的潜在致突变性的指标， 有机体，致癌性。 测试的化学品将是 选自那些被提议用于致突变的， 致癌性或生殖毒性试验，或 国家毒理学计划或其他方面的特殊兴趣 NIEHS。 从该合同中获得的结果将用于协助 确定短期和长期动物试验的优先次序， 将提供资料，说明支持执行《公约》的行动机制， 长期动物毒性结果的解释。 完成 这些研究还将进一步发展 遗传毒性数据库，将用于确定 体内和体外遗传学之间的一致性水平 毒性试验和体外结果的预测性 啮齿动物致癌作用。

The objective of this contract is to test approximately 25 chemicals per year for mutagenicity using the in vitro Salmonella mutagenicity test. The Salmonella test has become widely accepted as an indicator of a chemical's potential mutagenicity in higher organisms, and of carcinogenicity. The chemicals tested will be selected fromamong those that are proposed for mutagenicity, carcinogenicity, or reproductive toxicity testing, or are of special interest to the National Toxicology Program or others in the NIEHS. The results obtained from this contract will be used to assist in setting priorities for short- and longterm animal testing, and will provide information on mechanisms of action to support the interpretations of long-term animal toxicity results. Completion of these studies will also allow for the further development of the genetic toxicity data base which will be used to determine the level of agreement between in vivo and in vitro genetic toxicity tests and the predictivity of in vitro results for rodent carcinogenesis.