CLINICAL CENTER FOR VIRAL ACTIVATION TRANSFUSION STUDY

病毒激活输血研究临床中心

• 批准号: 2660244
• 负责人: THOMAS A LANE
• 金额: $ 17.93万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-12-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2660244
• 关键词: HIV infections; Herpesviridae disease; blood filtration; cytomegalovirus; gamma radiation; human immunodeficiency virus 1; human subject; human therapy evaluation; leukocyte activation /transformation; leukocyte transfusion; prognosis; radiobiology; virus infection mechanism

This study's objective is to determine if transfusion is followed by the activation of HIV-1 and Cytomegalovirus (CMV) in HIV-1 infected persons and thereby adversely affecting prognosis. It also will evaluate the role of donor leukocytes producing this activation by examining the effect of removing leukocytes by filtration or abolishing their ability to proliferate by gamma irradiation. Finally, the study will examine the persistence of donor lymphocytes after transfusion. The study consists of 11 clinical sites, a central laboratory, and a medical coordinating center.

这项研究的目的是确定输血后是否有 HIV-1感染者中HIV-1和巨细胞病毒（CMV）的活化 从而不利地影响预后。 它还将评估 供体白细胞产生这种激活的影响， 通过过滤去除白细胞或消除其 通过伽马射线照射增殖。 最后，研究将审查 输血后供体淋巴细胞的持久性。 该研究由11个临床研究中心、一个中心实验室和一个 医疗协调中心。