RETINOID MEDIATED ANTICANCER ACTIVITIES

描述：近年来取得的进步极大地改善了 对维甲酸作用的分子机制的了解，现在允许 维甲酸的设计是高度选择性的，比天然的更有效 化合物，并承诺有更少的副作用。在这份提案中， 肺癌细胞将作为模型系统进行研究，具有一系列新颖的 维甲酸已显示出良好的抗癌活性。申请人 将他的新奇类维A酸的活性与维甲酸进行比较 一系列不同的肺癌细胞系，包括非小细胞和 小细胞肺癌细胞，并将分析其分子机制 维甲酸类化合物增强的抗癌活性。就像现在这样 不太可能找到一种专门治疗肺部的药物 癌症，申请者还将检查他的高度合作 活性维甲酸和其他制剂，包括维生素D3(VD)和干扰素 (IFNS)。这些调查旨在提供有关 抑制肺癌细胞作用的分子机制 成长。

DESCRIPTION: Progress made in recent years has greatly improved the understanding of the molecular mechanisms of retinoid action and now allows the design of retinoids which are highly selective, more potent than natural compounds, and also promise to have fewer side effects. In this proposal, lung cancer cells will be studied as a model system with a series of novel retinoids that have shown promising anti-cancer activities. The applicant will compare the activity of his novel retinoids to retinoic acid in a series of different lung cancer cell lines, including non-small cell and small cell lung cancer cells, and will analyze the molecular mechanisms underlying the enhanced anti-cancer activities of the retinoids. As it is unlikely that a single agent can be identified that specifically cures lung cancer, the applicant will also examine cooperativity between his highly active retinoids and other agents including vitamin D3 (VD) and interferons (IFNs). These investigations are designed to provide fundamental data on the molecular mechanisms of action related to inhibition of lung cancer cell growth.