HIV SHEDDING IN WOMEN--FACTORS INFLUENCING INFECTIVITY

女性艾滋病毒传播——影响感染性的因素

• 批准号: 2672787
• 负责人: JOAN K KREISS
• 金额: $ 21.15万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-15 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2672787
• 关键词: Africa; Candida albicans; Chlamydia trachomatis; HIV infections; Neisseria gonorrhoeae; Trichomonas vaginalis; cervix disorder; clinical research; communicable disease transmission; contraceptives; estradiol; female; human immunodeficiency virus 1; human subject; menstrual cycle; microorganism culture; polymerase chain reaction; pregnancy; progesterone; prostitution; retinoids; sexually transmitted diseases; virus infection mechanism

DESCRIPTION (adapted from Abstract): Improved understanding of factors which affect infectivity of women may lead to development of preventive interventions for heterosexual and perinatal transmission. The major goal of this project is to define the prevalence, quantity, and correlates of HIV DNA and RNA in cervical and vaginal secretions of HIV seropositive women. A cross-sectional study of 400 prostitutes in Mombasa, Kenya will be conducted to evaluate the association between genital mucosal HIV and CD4 level, hormonal contraception, pregnancy, cervical ectopy, sexually-transmitted diseases, local inflammation, pH, estradiol, progesterone, and vitamin A. In addition, three substudies will be conducted. In the first, 300 women with Neisseria gonorrhoeae, Chlamydia trachomatis, Trichmonas vaginalis, Candida ssp., or bacterial vaginosis (and, in particular, absence of hydrogen peroxide producing lactobacilli) will be evaluated before and after treatment of the genital infection to document reduction in HIV shedding following resolution of sexually-transmitted diseases. In the second, 60 women will be studied before and after institution of hormonal contraception with either oral contraceptive pills or injectable progesterone to determine whether method of contraception has a measurable effect on HIV shedding. In the third, a group of 10 women will be evaluated daily for one month to define the pattern of cervical and vaginal HIV and HIV specific antibodies in relation to menstrual cycle. In this proposed study the researchers will characterize factors which affect HIV infectivity in women and may lead to new intervention strategies to prevent transmission.

描述（改编自摘要）：提高对因素的理解 影响妇女传染性的因素可能导致预防性的发展， 对异性性传播和围产期传播采取干预措施。 的主要目标 该项目的目的是确定艾滋病毒的流行率、数量和相关因素， HIV血清阳性妇女宫颈和阴道分泌物中的DNA和RNA 一 将对肯尼亚蒙巴萨的400名妓女进行横断面研究 评估生殖道粘膜HIV与CD4水平之间的关系， 激素避孕，妊娠，宫颈异位，性传播 疾病、局部炎症、pH、雌二醇、孕酮和维生素A。在 此外，还将进行三项次级研究。 在第一阶段，300名妇女 淋病奈瑟菌、沙眼衣原体、阴道毛单胞菌、念珠菌 ssp.，或细菌性阴道病（特别是缺乏氢 产生过氧化物的乳酸杆菌）将在 治疗生殖器感染，记录艾滋病毒散发减少情况 在解决性传播疾病后。 第二，60 将研究女性在激素避孕前后的情况 口服避孕药或注射黄体酮， 避孕方法是否对艾滋病毒脱落有可测量的影响。 在 第三，一组10名妇女将每天进行评估，为期一个月， 确定宫颈和阴道HIV和HIV特异性抗体的模式 与月经周期有关。 在这项研究中，研究人员将 描述影响妇女艾滋病毒感染的因素，并可能导致 采取新的干预策略防止传播。