HIV SHEDDING IN WOMEN--FACTORS INFLUENCING INFECTIVITY

描述(改编自摘要)：改进了对因素的理解 哪些影响妇女的传染性可能导致预防性的发展 对异性恋和围产期传播的干预。主要目标是 这个项目的目的是定义艾滋病毒的流行率、数量和相关因素 HIV血清阳性妇女宫颈和阴道分泌物中的DNA和RNA一个 将对肯尼亚蒙巴萨的400名妓女进行横断面研究 为了评估生殖器粘膜艾滋病毒与CD4水平之间的关系， 荷尔蒙避孕、怀孕、宫颈异位、性传播 疾病、局部炎症、pH、雌二醇、黄体酮和维生素A。 此外，还将进行三项分研究。在第一个实验中，300名女性 淋球菌、沙眼衣原体、阴道毛滴虫、念珠菌 或细菌性阴道病(尤其是无氢 产生过氧化氢的乳酸菌)将在前后进行评估 减少HIV脱落率中生殖器感染的治疗 随着性传播疾病的解决。在第二个，60 将对女性进行激素避孕前后的研究 使用口服避孕药或注射孕酮来确定 避孕方法对HIV的传播是否有显著影响。在……里面 第三，由10名女性组成的小组将在一个月内每天接受评估，以 明确宫颈和阴道HIV和HIV特异性抗体的类型 与月经周期有关。在这项拟议的研究中，研究人员将 描述影响女性艾滋病毒传染性的因素，并可能导致 预防传播的新干预策略。

DESCRIPTION (adapted from Abstract): Improved understanding of factors which affect infectivity of women may lead to development of preventive interventions for heterosexual and perinatal transmission. The major goal of this project is to define the prevalence, quantity, and correlates of HIV DNA and RNA in cervical and vaginal secretions of HIV seropositive women. A cross-sectional study of 400 prostitutes in Mombasa, Kenya will be conducted to evaluate the association between genital mucosal HIV and CD4 level, hormonal contraception, pregnancy, cervical ectopy, sexually-transmitted diseases, local inflammation, pH, estradiol, progesterone, and vitamin A. In addition, three substudies will be conducted. In the first, 300 women with Neisseria gonorrhoeae, Chlamydia trachomatis, Trichmonas vaginalis, Candida ssp., or bacterial vaginosis (and, in particular, absence of hydrogen peroxide producing lactobacilli) will be evaluated before and after treatment of the genital infection to document reduction in HIV shedding following resolution of sexually-transmitted diseases. In the second, 60 women will be studied before and after institution of hormonal contraception with either oral contraceptive pills or injectable progesterone to determine whether method of contraception has a measurable effect on HIV shedding. In the third, a group of 10 women will be evaluated daily for one month to define the pattern of cervical and vaginal HIV and HIV specific antibodies in relation to menstrual cycle. In this proposed study the researchers will characterize factors which affect HIV infectivity in women and may lead to new intervention strategies to prevent transmission.