Do sex steroids regulate tear lipid production in human meibomian glands?

性类固醇是否调节人类睑板腺泪脂的产生？

• 批准号: DP190103045
• 负责人: A/Prof Blanka-Anna Golebiowski
• 金额: $ 31.61万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190103045
• 关键词: Do; sex; steroids; regulate; tear

This project aims to determine whether production of tear film lipids by meibomian gland cells is regulated by sex steroids. The tear film is essential to eyesight. It protects and nourishes the eye surface to maintain transparency to enable light to reach the retina. To guarantee these functions, exquisite control of tear film composition is required, including the outer lipid layer. Sex hormones, including oestrogen, may control production of the lipid layer by meibomian glands in the eyelid, but this has not been confirmed in humans. This project aims to show whether meibomian glands produce sex hormones, which then control production of tear lipids. This new knowledge will improve our understanding of how the tear film maintains clear vision.

本项目旨在确定睑板腺细胞的泪膜脂的产生是否受性类固醇的调节。泪膜对视力很重要。它保护和滋养眼睛表面，保持透明，使光线能够到达视网膜。为了保证这些功能，需要对泪膜成分进行精细的控制，包括外脂层。包括雌激素在内的性激素可能控制眼睑内睑板腺脂质层的生成，但这一点在人类身上尚未得到证实。该项目旨在证明睑板腺是否会产生性激素，从而控制泪脂的产生。这一新知识将提高我们对泪膜如何保持清晰视力的理解。