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MORPHOLOGICAL DYNAMICS OF LIVING NEURONS IN SLICES

MORPHOLOGICAL DYNAMICS OF LIVING NEURONS IN SLICES
切片中活神经元的形态动力学
批准号:
2609542
负责人:
Steve M Potter
金额:
$3.15万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
未结题
起止时间:
1997-11-15 至

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中文摘要
翻译
本研究探索了一种新的器官型培养系统的潜力
英文摘要
This study explores the potentials of a new organotypic culture system as a model for in vivo neural transplants, and as a tool for studying the morphological correlates of synaptic plasticity. I will study the development of embryonic rat hippocampal neurons transplanted to cultured hippocampal slices from neonatal rats. I will observe the process of transplant integration while it happens, using time-lapse 2-photon microscopy. I will observe the effects of slice age and transplant location on the neurite outgrowth of transplanted CA1 and CA3 pyramidal neurons. I will quantify dynamic morphological parameters of the transplanted cells, such as neurite growth and retraction rates, branch formation, and cell body migration, in comparison to those of the host cells. Depolarizing agents will be applied to slices during timelapse imaging to see how the overall level of spontaneous activity in the slice influences neural morphology. The findings will be useful to those interested in the bases of learning and memory, and the potential for hippocampal transplants to ameliorate the effects of neurodegenerative disorders, such as Alzheimer's disease.
期刊论文(3)
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会议论文
Neural transplant staining with DiI and vital imaging by 2-photon laser-scanning microscopy.
使用 DiI 进行神经移植染色,并通过 2 光子激光扫描显微镜进行生命成像。
DOI: --
发表时间: 1996
期刊: Scanning microscopy. Supplement
影响因子: --
作者: [Potter,SM, Pine,J, Fraser,SE]
通讯作者: Fraser,SE
Optogenetic Population Clamp to Study Long-term Plasticity in Vitro
  • 批准号:
    8346815
  • 项目类别:
  • 资助金额:
    $31.82万
  • 财政年份:
    2012
  • 负责人:
    Steve M Potter
  • 依托单位:
Chemical Reward Systems for Embodied Cultured Networks
  • 批准号:
    6815104
  • 项目类别:
  • 资助金额:
    $14.69万
  • 财政年份:
    2004
  • 负责人:
    Steve M Potter
  • 依托单位:
Chemical Reward Systems for Embodied Cultured Networks
  • 批准号:
    6911547
  • 项目类别:
  • 资助金额:
    $14.69万
  • 财政年份:
    2004
  • 负责人:
    Steve M Potter
  • 依托单位:
MULTIELECTRODE & IMAGING ANALYSIS OF CULTURED NETWORKS
  • 批准号:
    6574749
  • 项目类别:
  • 资助金额:
    $4.15万
  • 财政年份:
    1999
  • 负责人:
    Steve M Potter
  • 依托单位:
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