Mechanisms of itch - from endosomal signalling to neural circuits

瘙痒机制 - 从内体信号传导到神经回路

• 批准号: DP190102854
• 负责人: A/Prof Wendy Imlach
• 金额: $ 28.34万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-06-23 至 2024-12-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102854
• 关键词: Mechanisms; itch; endosomal; signalling; neural

This project aims to investigate the cellular and circuit mechanisms of itch transmission in the spinal cord by defining the activation and propagation of itch-specific signals. This project expects to generate new knowledge in the area of neuronal signalling and circuitry using novel electrophysiological approaches that target and manipulate specific nerves and cellular components. The project will characterise signalling within specific spinal subcircuits in order to understand the mechanisms of receptor activation and signalling, and investigate how circuit activity is regulated. This project expects to advance fundamental understanding of itch signalling in the nervous system and provide avenues for future therapeutics.

该项目旨在通过定义瘙痒特异性信号的激活和传播来研究脊髓中瘙痒传播的细胞和电路机制。该项目期望使用针对和操纵特定神经和细胞成分的新型电生理学方法，产生神经信号和电路领域的新知识。该项目将表征特定脊髓亚回路内的信号传导，以了解受体激活和信号传导的机制，并研究回路活动是如何调节的。该项目期望增进对神经系统中瘙痒信号传导的基本了解，并为未来的治疗提供途径。