REPETITIVE BEHAVIOR PATTERNS--DEVELOPMENT & NEUROBIOLOGY

描述：(改编自申请者摘要)：刻板印象是指 重复、有节奏、地形不变的行为，以及 没有明显的作用。尽管在许多地方都可以观察到刻板印象 物种在不同的环境中，这种行为通常是相关的，在 人类，患有各种精神、神经和发育障碍， 而且，在动物身上，有不利的环境环境。虽然研究 利用药理学模型对刻板印象的行为进行了识别 重要的大脑机制，对其神经生物学基础知之甚少 或在动物或人类身上自发刻板印象的作用。这个 研究人员建议研究糖尿病的发生和神经生物学基础。 野生型鼠形啮齿动物的异常刻板行为。一间实验室 建立的啮齿动物模型为这类研究提供了显著的优势 由于对这些物种的神经生物学了解很多，而且 大量的动物可以快速繁殖。拟议的研究将有三个目标： 描述鹿小鼠刻板印象行为的发展； 及早预防不正常刻板行为的发展 环境浓缩；并确定重要的神经生物学 刻板印象发展和表达的调节机制 行为。成功完成拟议的研究将提供 关于刻板印象的病理生理和治疗的重要信息 人类的运动障碍。此外，这些研究将涉及基本的 调节环境诱导的刻板印象行为的大脑机制， 以及这种行为对生物有机体的作用。

DESCRIPTION:(Adapted from applicant's abstract): Stereotypy refers to behavior that is repetitive, rhythmical, topographically invariant, and without an obvious function. Although stereotypies can be observed in many species in different contexts, such behavior is typically associated, in humans, with various psychiatric, neurological, and developmental disorders, and, in animals, with adverse environmental circumstances. Although studies using pharmacological models of stereotyped behavior have identified important brain mechanisms, little is known about the neurobiological basis or function of spontaneous stereotypes in animals or humans. The investigators propose to study the development and neurobiological basis of abnormal stereotyped behavior in wild-type muroid rodents. A laboratory based rodent model offers significant advantages for these kinds of studies as much is known about the neurobiology of these species and large numbers of animals can be rapidly bred. The proposed studies will have three aims: To characterize the development of stereotyped behavior in deer mice; to prevent the development of abnormal stereotyped behavior by early environmental enrichment; and to identify important neurobiological mechanisms that mediate the development and expression of stereotyped behavior. Successful completion of the proposed studies will provide important information about the pathophysiology and treatment of stereotypic movement disorder in humans. Moreover, these studies will address basic brain mechanisms that mediate environmentally-induced stereotyped behavior, and the function of such behavior for the biological organism.