REPETITIVE BEHAVIOR PATTERNS--DEVELOPMENT & NEUROBIOLOGY
REPETITIVE BEHAVIOR PATTERNS--DEVELOPMENT & NEUROBIOLOGY
批准号:
2675542
负责人:
MARK H LEWIS
金额:
$15.98万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-04-01 至 2000-03-31
关键词:
Peromyscus RNase protection assay animal developmental psychology animal ecology autoradiography behavioral /social science research tag dopamine receptor endogenous opioid ethology high performance liquid chromatography image processing in situ hybridization instinct neurobiology operant conditionings radioimmunoassay receptor binding receptor expression statistics /biometry
中文摘要
描述:(改编自申请者摘要):刻板印象是指
重复、有节奏、地形不变的行为,以及
没有明显的作用。尽管在许多地方都可以观察到刻板印象
物种在不同的环境中,这种行为通常是相关的,在
人类,患有各种精神、神经和发育障碍,
而且,在动物身上,有不利的环境环境。虽然研究
利用药理学模型对刻板印象的行为进行了识别
重要的大脑机制,对其神经生物学基础知之甚少
或在动物或人类身上自发刻板印象的作用。这个
研究人员建议研究糖尿病的发生和神经生物学基础。
野生型鼠形啮齿动物的异常刻板行为。一间实验室
建立的啮齿动物模型为这类研究提供了显著的优势
由于对这些物种的神经生物学了解很多,而且
大量的动物可以快速繁殖。拟议的研究将有三个目标:
描述鹿小鼠刻板印象行为的发展;
及早预防不正常刻板行为的发展
环境浓缩;并确定重要的神经生物学
刻板印象发展和表达的调节机制
行为。成功完成拟议的研究将提供
关于刻板印象的病理生理和治疗的重要信息
人类的运动障碍。此外,这些研究将涉及基本的
调节环境诱导的刻板印象行为的大脑机制,
以及这种行为对生物有机体的作用。
英文摘要
DESCRIPTION:(Adapted from applicant's abstract): Stereotypy refers to
behavior that is repetitive, rhythmical, topographically invariant, and
without an obvious function. Although stereotypies can be observed in many
species in different contexts, such behavior is typically associated, in
humans, with various psychiatric, neurological, and developmental disorders,
and, in animals, with adverse environmental circumstances. Although studies
using pharmacological models of stereotyped behavior have identified
important brain mechanisms, little is known about the neurobiological basis
or function of spontaneous stereotypes in animals or humans. The
investigators propose to study the development and neurobiological basis of
abnormal stereotyped behavior in wild-type muroid rodents. A laboratory
based rodent model offers significant advantages for these kinds of studies
as much is known about the neurobiology of these species and large numbers
of animals can be rapidly bred. The proposed studies will have three aims:
To characterize the development of stereotyped behavior in deer mice; to
prevent the development of abnormal stereotyped behavior by early
environmental enrichment; and to identify important neurobiological
mechanisms that mediate the development and expression of stereotyped
behavior. Successful completion of the proposed studies will provide
important information about the pathophysiology and treatment of stereotypic
movement disorder in humans. Moreover, these studies will address basic
brain mechanisms that mediate environmentally-induced stereotyped behavior,
and the function of such behavior for the biological organism.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Optogenetic control of neuronal pathways that mediate repetitive behavior
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批准号:9282470
-
项目类别:
-
资助金额:$18.75万
-
财政年份:2016
-
负责人:MARK H LEWIS
-
依托单位:
Developing a novel treatment for restricted inflexible behavior
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批准号:8251190
-
项目类别:
-
资助金额:$17.81万
-
财政年份:2011
-
负责人:MARK H LEWIS
-
依托单位:
Developing a novel treatment for restricted inflexible behavior
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批准号:8114289
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项目类别:
-
资助金额:$21.53万
-
财政年份:2011
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负责人:MARK H LEWIS
-
依托单位:
Development of Persistent Repetitive Behavior in Animals
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批准号:7652493
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项目类别:
-
资助金额:$36.3万
-
财政年份:2009
-
负责人:MARK H LEWIS
-
依托单位:
Development of Persistent Repetitive Behavior in Animals
-
批准号:8439309
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项目类别:
-
资助金额:$37.3万
-
财政年份:2009
-
负责人:MARK H LEWIS
-
依托单位:
Development of Persistent Repetitive Behavior in Animals
-
批准号:8922052
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项目类别:
-
资助金额:$29.22万
-
财政年份:2009
-
负责人:MARK H LEWIS
-
依托单位:
Development of Persistent Repetitive Behavior in Animals
-
批准号:8536674
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项目类别:
-
资助金额:$34.61万
-
财政年份:2009
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负责人:MARK H LEWIS
-
依托单位:
Development of Persistent Repetitive Behavior in Animals
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批准号:7844896
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项目类别:
-
资助金额:$36.25万
-
财政年份:2009
-
负责人:MARK H LEWIS
-
依托单位:
Development of the Florida Autism Center of Excellence
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批准号:6475127
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项目类别:
-
资助金额:$14.5万
-
财政年份:2001
-
负责人:MARK H LEWIS
-
依托单位:
REPETITIVE BEHAVIOR PATTERNS--DEVELOPMENT & NEUROBIOLOGY
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批准号:2034945
-
项目类别:
-
资助金额:$15.52万
-
财政年份:1997
-
负责人:MARK H LEWIS
-
依托单位:
REPETITIVE BEHAVIOR PATTERNS--DEVELOPMENT & NEUROBIOLOGY
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批准号:2890850
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项目类别:
-
资助金额:$16.46万
-
财政年份:1997
-
负责人:MARK H LEWIS
-
依托单位:
FLORIDA NEUROPSYCHIATRIC RESEARCH
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批准号:2675181
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项目类别:
-
资助金额:$48.95万
-
财政年份:1995
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负责人:MARK H LEWIS
-
依托单位:
FLORIDA NEUROPSYCHIATRIC RESEARCH
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批准号:2890591
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项目类别:
-
资助金额:$37.92万
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财政年份:1995
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负责人:MARK H LEWIS
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依托单位:
STEREOTYPIES & MENTAL RETARDATION: NEUROBIOLOGICAL BASIS
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批准号:6125697
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项目类别:
-
资助金额:$14.24万
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财政年份:1992
-
负责人:MARK H LEWIS
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依托单位:
Stereotypies & Mental Retardation: Neurobiological Basis
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批准号:6658180
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项目类别:
-
资助金额:$16.31万
-
财政年份:1992
-
负责人:MARK H LEWIS
-
依托单位:
Stereotypies & Mental Retardation: Neurobiological Basis
-
批准号:6916553
-
项目类别:
-
资助金额:$16.37万
-
财政年份:1992
-
负责人:MARK H LEWIS
-
依托单位:
STEREOTYPIES & MENTAL RETARDATION--NEUROBIOLOGICAL BASIS
-
批准号:2202941
-
项目类别:
-
资助金额:$10.11万
-
财政年份:1992
-
负责人:MARK H LEWIS
-
依托单位:
Stereotypies & Mental Retardation: Neurobiological Basis
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批准号:7105612
-
项目类别:
-
资助金额:$15.98万
-
财政年份:1992
-
负责人:MARK H LEWIS
-
依托单位:
STEREOTYPIES & MENTAL RETARDATION: NEUROBIOLOGICAL BASIS
-
批准号:2025463
-
项目类别:
-
资助金额:$13.03万
-
财政年份:1992
-
负责人:MARK H LEWIS
-
依托单位:
Stereotypies & Mental Retardation: Neurobiological Basis
-
批准号:6542266
-
项目类别:
-
资助金额:$16.31万
-
财政年份:1992
-
负责人:MARK H LEWIS
-
依托单位:
海外基金