ENVIRONMENTAL TEMPERATURE, SNS DEVELOPMENT AND OBESITY

该项目的长期目标是确定环境 发育期间的暴露有助于获得肥胖或 成年人的高血压特征。如果成功的话， 制定早期干预策略， 预防这些疾病的发展。建议的研究 该应用解决了热环境的持久影响 其中新生动物是在动物对 成年后变得肥胖。在子宫内生命热稳态 由母体机制维持，而新生动物出生后 越来越依靠自己来保护体温。是 申请人的论点是，体温调节要求 对新生生物体的影响及其在生命早期对它们的反应 影响这些生理系统的调节直到成年。在 特别是，这项调查侧重于早期的影响， 环境温度对交感神经发育的影响 系统（SNS）。计划进行的研究具体涉及环境 在生命的头两个月，温度会影响 外周组织和/或中枢的交感神经支配 调节SNS活动以响应温度的变化， 饮食.研究还将检查神经生长因子（NGF）的作用， 神经营养素-3介导外周交感神经系统的变化 早期热暴露后的神经支配。是否这些 假设的影响，神经生长因子是由于当地生产的神经生长因子在 靶组织本身或循环水平的神经生长因子将被 测定饲养温度对大鼠血压和血压的影响 还将检查成年动物的葡萄糖耐量。

The long-term goal of this project is to determine how environmental exposures during development contribute to acquisition of obese or hypertensive traits in the adult. If successful, it may be possible to devise strategies for early intervention which might prevent or at least forestall the development of these disorders. The studies proposed in this application address the lasting influence of the thermal environment in which neonatal animals are reared on an animal's susceptibility to become obese as an adult. During intrauterine life thermal homeostasis is maintained by maternal mechanisms, while after birth neonatal animals are increasingly self-reliant for defense of body temperature. It is the contention of the applicants that the thermoregulatory demands placed upon the newborn organism and its response to them early in life will affect the regulation of these physiological systems into adulthood. In particular, this investigation focuses upon the impact of early environmental temperature on the development of the sympathetic nervous system (SNS). Studies planned address specifically whether environmental temperature during the first two months of life affects the density of sympathetic innervation in peripheral tissues and/or the central regulation of SNS activity in response to alterations in temperature and diet. Studies will also examine the role of nerve growth factor (NGF) and neurotrophin-3 in mediating the changes in peripheral sympathetic innervation consequent to early thermal exposure. Whether these postulated effects of NGF are due to local production of NGF in the target tissues themselves or to circulating levels of NGF will be determined. The impact of rearing temperature on blood pressure and glucose tolerance in adult animals will also be examined.