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HUMAN MITOTIC CHECKPOINT GENE--HSMAD2

HUMAN MITOTIC CHECKPOINT GENE--HSMAD2
人类有丝分裂检查点基因--HSMAD2
批准号：
2701769
负责人：
ROBERT I BENEZRA
金额：
$17.83万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-05-01 至 2000-04-30
来源：
https://reporter.nih.gov/project-details/2701769
关键词：
HeLa cells SDS polyacrylamide gel electrophoresis Xenopus oocyte alleles cell cycle cell growth regulation embryonic stem cell flow cytometry gene mutation immunoprecipitation laboratory mouse mitotic spindle apparatus neoplasm /cancer genetics neoplastic process phenotype polymerase chain reaction site directed mutagenesis western blottings

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英文摘要
The aims of this proposal are to define how human MAD2 (hsMAD2) functions as a mitotic checkpoint gene and to determine if disruption of hsMAD2 contributes to the generation of neoplasia in mouse models. hsMAD2 is the human homolog of a mitotic checkpoint gene first identified in budding yeast (scMAD2). The investigator proposes to test the hypothesis is that the biochemical mechanism underlying human MAD2 checkpoint function is its ability to inhibit the APC through its interactions with Cdc16 and Cdc27. In addition, MAD2 will be disrupted in both ES cells and mice to determine the contribution made by MAD2 to mitotic checkpoint control in mammalian cells.
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