HERITAGE--GENETICS, RESPONSE TO EXERCISE, RISK FACTORS

遗产家庭研究的目的是记录 对耐力运动训练的心血管和代谢反应， 以及遗传因素对伴随反应的贡献， 心血管疾病（CVD）和糖尿病（NIDDM）的危险因素。 一 由5所大学组成的联合会正在进行这项研究。 在第1阶段91992- 1998年），约765名久坐不动的受试者进行了运动训练， 同样的节目20周。 在最终的主文件中 来自98个高加索血统家庭的约495名个体， 父母和生物成年后代和270个个体， 黑人家庭 训练前后，最大摄氧量和 对次最大和最大剂量的心血管和代谢反应 锻炼是测量的。 血浆脂质、脂蛋白和酶， 胰岛素和葡萄糖对静脉内葡萄糖负荷反应，血浆 性类固醇和糖皮质激素，静息和运动血压， 并对体脂、局部脂肪分布和内脏脂肪进行评估。 在拟议的第二阶段，将进行一系列非遗传研究。 在Heritage家族数据集上进行。 生理上， 最大和次最大的行为和社会决定因素 久坐状态下的心肺耐力指标和 对培训的反应将进行调查， 年龄、性别和种族的贡献。 将进行类似的分析 研究中监测的CVD和NIDDM风险因素。 遗传分析将确定遗传力水平，并测试 父母效应、主基因效应和分离 这些模式将用于发展关于遗传学的假设， 耐力运动的反应基础。 候选人小组 基因将被分型并用于关联和连锁研究。 将使用骨骼肌转录本的差异显示分析 来识别新的候选基因， 锻炼的 最后，将进行全基因组搜索， 候选基因组区域和位置候选基因 心肺耐力反应与CVD和NIDDM风险 因子表型 遗产家庭研究的这一阶段 应该增加我们对黑人之间差异的理解 和白人的常见CVD和NIDDM危险因素， 久坐状态和适应规律耐力的遗传学 运动在那里的风险因素，重点是潜在的种族 差异 这份申请来自德克萨斯大学奥斯汀分校 临床中心。

The aim of the HERITAGE Family Study is to document cardiovascular and metabolic responses to endurance exercise training, and the contribution of genetic factors to the concomitant response of cardiovascular disease (CVD) and diabetes (NIDDM) risk factors. A consortium of 5 universities is conducting the study. In Phase 1 91992- 1998), about 765 sedentary subjects were exercise-trained with the same program for 20 weeks. There will be in the final master file about 495 individuals from 98 families of Caucasian descent with both parents and biological adult offspring and 270 individuals from 102 Black families. Before and after training, maximal oxygen uptake and cardiovascular and metabolic responses to submaximal and maximal exercise were measured. Plasma lipids, lipoproteins and enzymes, insulin and glucose response to an intravenous glucose load, plasma sex steroids and glucocorticoids, resting and exercise blood pressures, and body fat, regional fat distribution and visceral fat were assessed. During the proposed Phase 2, a series of nongenetic studies will be undertaken on the HERITAGE family dataset. Physiological, behavioral and social determinants on maximal and submaximal indicators of cardiorespiratory endurance in the sedentary state an din the response to training will be investigated taking into account the contributions of age, gender and race. Similar analysis will be carried out on the CVD and NIDDM risk factors monitored in the study. Genetic analyses will determine the heritability levels, and test for paternal or maternal effects, major gene effects and segregation patterns which will be used to develop hypotheses concerning genetic bases of the response to endurance exercise. A panel of candidate genes will be typed and used for association and linkage studies. Differential display analysis of skeletal muscle transcripts will be used to identify new candidate genes for the response to endurance exercise. Finally, a genome wide search will be undertaken to locate candidate genomic regions and positional candidate genes for the response of cardiorespiratory endurance and CVD and NIDDM risk factor phenotypes. This phase of the HERITAGE Family Study should increase our understanding of the differences between Blacks and Whites for common CVD and NIDDM risk factors in the sedentary state and of the genetics of adaptation to regular endurance exercise in there risk factors with an emphasis on potential racial differences. This application is from the University of Texas at Austin Clinical Center.