CONTROLLING PRETERM LABOR: A NEW MOLECULAR APPROACH

早产和分娩代表了一个主要的健康问题， 美国和世界各地。 最近的统计数据表明， 早产率在过去10年中没有变化，尽管 努力解决这个问题。 早产率已经 仍然保持在所有交付量的大约8%到10%。 尽管大约30%的早产与 在母亲感染的情况下， 特发性的 早产儿占我们新生儿的70% 死亡率，早产儿护理的估计费用为 每年约10亿美元。 许多治疗剂已被应用作为治疗， 早产，成功有限，与潜力相关 对母婴健康的影响。 没有治疗是有效的， 让怀孕的人能够足月。 成功是相对的，包括 延迟交货的好处只有几天开始 适当的类固醇治疗 在很大程度上，这种治疗方法的失败反映了我们的不完整。 了解人类劳动的规律。 该提案提出 一种新的方法来解决控制早产的基础上，最近的新的 对劳动的人类特定方面的见解。

Preterm labor and delivery represent a major health problem in the United States and around the world. Recent statistics indicate that the rate of preterm births has not changed over the past 10 years, in spite of efforts to address this problem. The rate of preterm birth has remained at approximately 8 percent to 10 percent of all deliveries. Although approximately 30 percent of preterm deliveries are associated with maternal infection, the larger fraction of preterm births are idiopathic. Preterm infants account for 70 percent of our neonatal mortality, and the estimated cost for the care of premature infants is approximately billion dollars annually. A number of therapeutic agents have been applied as treatments for preterm labor, and success has limited and associated with potential health consequences to mother and infant. No therapy is effective in allowing pregnancies to reach term. Success is relative, and includes the benefit of delay of delivery for only a few days to initiate appropriate steroid therapy. To a large degree this failure of therapeutics reflects our incomplete understanding of the regulation of human labor. This proposal presents a novel approach to address control of preterm labor based on recent new insights into the human-specific aspects of labor.