ORNITHINE DECARBOXYLASE ANTIZYME (ODC-AZ) IN ORAL CANCER

鸟氨酸脱羧酶抗酶 (ODC-AZ) 在口腔癌中的应用

• 批准号: 2501276
• 负责人: TAKANORI TSUJI
• 金额: $ 4.41万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2501276
• 关键词: Retroviridae; athymic mouse; complementary DNA; enzyme activity; gene expression; gene induction /repression; gene mutation; gene rearrangement; genetic library; genetic promoter element; keratinocyte; messenger RNA; neoplasm /cancer genetics; neoplastic cell; nucleic acid sequence; oral pharyngeal neoplasm; ornithine decarboxylase; polymerase chain reaction; tissue /cell culture; transfection /expression vector; tumor suppressor genes

DESCRIPTION: This is a proposal to test the hypothesis that the ornithine decarboxylase-antizyme gene (ODC-Az) is a tumor suppressor gene in oral cancer Under Aim 1 the tumor suppressing-potential will be evaluated in malignant hamster oral keratinocytes by introducing the gene in an inducible retrovirus system. Under Aim 2 the regulatory region of the gene will be examined in orde to find if loss of expression is due to changes in that region.

描述：这是检验鸟氨酸的假设的建议 脱羧酶 - 抗杀解酶基因（ODC-AZ）是口服中的肿瘤抑制基因 AIM 1下的癌症1将在 恶性仓鼠口服角质形成细胞，通过在诱导型中引入基因 逆转录病毒系统。 在AIM 2下，基因的调节区域将是 在orde中检查以发现是否由于变化而导致表达丧失 地区。