ORNITHINE DECARBOXYLASE ANTIZYME (ODC-AZ) IN ORAL CANCER

描述：这是一项用来检验鸟氨酸 脱羧酶-抗酶基因(ODC-Az)是口腔肿瘤抑制基因 目标1下的癌症肿瘤抑制潜力将在 将该基因导入诱导剂诱导的恶性仓鼠口腔角质形成细胞 逆转录病毒系统。在目标2下，基因的调节区将是 检查以找出表达的丧失是否是由于 区域。

DESCRIPTION: This is a proposal to test the hypothesis that the ornithine decarboxylase-antizyme gene (ODC-Az) is a tumor suppressor gene in oral cancer Under Aim 1 the tumor suppressing-potential will be evaluated in malignant hamster oral keratinocytes by introducing the gene in an inducible retrovirus system. Under Aim 2 the regulatory region of the gene will be examined in orde to find if loss of expression is due to changes in that region.