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DENTIN MATRIX PROTEIN 1 EXPRESSION IN ODONTOBLAST CELL

DENTIN MATRIX PROTEIN 1 EXPRESSION IN ODONTOBLAST CELL
牙本质基质蛋白 1 在成牙本质细胞中的表达
批准号：
2701019
负责人：
JIAN Q. FENG
金额：
$0.01万
依托单位：
UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-05-01 至 1998-10-31
来源：
https://reporter.nih.gov/project-details/2701019
关键词：
animal genetic material tag cell type dentin gene expression genetic promoter element genetic regulation human genetic material tag in situ hybridization methylation nucleic acid sequence odontoblasts transcription factor transfection transfection /expression vector

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英文摘要
This revised proposal is designed to characterize the regulation of expression of the dentin matrix protein - 1 (DMP-1) gene. DMP-1 is a secreted protein found predominately in dentin, but DMP-1 mRNA is also detected by in situ hybridization in osteoblasts. The hypothesis to be tested is that tissue specificity is due to interactions between transcription factors and gene DNA sequences in the DMP-1 promoter and upstream regions. The specific aims are to (1) characterize and compare DNA sequences for the human and murine DMP-1 genes; (2) determine upstream regions that confer tissue-specific expression using gene transfer of expression vectors into cultured odontoblasts and other cell types; and (3) to determine the importance of methylation in tissue specific expression.
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