ANTIBODY ACTION MECHANISM AGAINST CRYPTOCOCCUS NEOFORMAN

新型隐球菌抗体作用机制

• 批准号: 2671381
• 负责人: Marta L. Feldmesser
• 金额: $ 9.13万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2671381
• 关键词: Cryptococcus neoformans; antifungal antibody; ascites; cytokine; immunoglobulin G; immunomodulators; immunotherapy; laboratory mouse; lung; molecular pathology; monoclonal antibody; mycosis; nitric oxide; opsonin; respiratory infections; virulence

DESCRIPTION: The candidate indicates that Cryptococcus neoformans causes life threatening infections in 6-8% of patients with AIDS, that C. neoformans has a polysaccharide capsule which is a determinant of virulence and is antiphagocytic, and that capsule binding antibodies are potent opsonins which have been shown to prolong survival in murine models following intravenous inoculation of the fungus. However, the fungus enters its host through the respiratory tree and little is known about the role of antibody immunity in pulmonary infections. This information is increasingly important given the ongoing development of a conjugate vaccine which elicits antibody formation. Preliminary data indicated that systemic antibody protects against a primary pulmonary C. neoformans infection. The overall theme of this application is to study the mechanism of the antibody mediated protection in pulmonary infections. Four aims are proposed. Aim 1 will determine the efficacy of antibody in modifying the course of pulmonary infection. Aim 2 will determine the mechanism of serum antibody protection in the lung. Aim 3 will explore the contribution of cytokine expression to antibody mediated protection in the lung. Aim 4 will determine the mechanisms of extrapulmonary dissemination of C. neoformans.

产品说明： 候选人指出，新型隐球菌导致生命 在6-8%的艾滋病患者中，C. 新生儿有一个多糖荚膜，这是毒力的决定因素 并且是抗吞噬细胞的，并且胶囊结合抗体是有效的 调理素已经显示出在鼠模型中延长存活 在静脉注射真菌后 然而，真菌进入 它的宿主通过呼吸树和鲜为人知的作用， 肺部感染的抗体免疫。 这些信息越来越 重要的是考虑到正在进行的缀合物疫苗的开发， 抗体形成。 初步数据表明，全身性抗体 防止原发性肺部感染新生儿感染。 整体 本申请的主题是研究抗体介导的 保护肺部感染。 提出了四个目标。 目标1将 确定抗体在改变肺结核病程中的功效 感染 目的2探讨血清抗体保护作用的机制 在肺部。 目的3将探讨细胞因子表达对 抗体介导的肺保护。 目标4将决定 探讨了C.新人类