MULTIDISCIPLINARY STUDIES OF NEURAL PLASTICITY IN SPACE

空间神经可塑性的多学科研究

• 批准号: 2735652
• 负责人: MURIEL D ROSS
• 金额: $ 21.26万
• 依托单位: NASA--AMES RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1999-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2735652
• 关键词: developmental neurobiology; ear hair cell; environmental adaptation; extraterrestrial environment; glutamate receptor; gravity; laboratory rat; neural plasticity; receptor expression; retina; scanning electron microscopy; vestibular apparatus

DESCRIPTION: (Adapted from the Applicant's Abstract.) This application will examine the hypothesis that during the altered inertial environment of orbital flight, plasticity and adaptive changes take place within the maculae of the vestibular organs. The flight portion of the study will involve electrophysiological recordings from the vestibular nerve of the rat in response to (sinusoidal) linear accelerations along unspecified axes. In parallel, maculas will be harvested from other animals for morphological and anatomical examination, including (a) serial reconstruction of the terminals and receptive fields of selected macular regions using electron-microscopic techniques, (b) changes in glutamate receptor gene expression at macular synapses, (c) changes in glutamate receptor protein in macular hair cells, and (d) changes in the otoconial mass, performed using scanning EM. The results from these experiments will be incorporated into a developing model of the peripheral vestibular system.

描述：（改编自申请人的摘要。）本申请 将检验这样一种假设，即在惯性环境改变的过程中， 在轨道飞行中，可塑性和适应性变化发生在 前庭器官的黄斑。研究的飞行部分将 涉及来自前庭神经的电生理记录， 大鼠对沿未指定方向沿着的（正弦）线性加速度的响应 轴。与此同时，将从其他动物身上采集黄斑， 形态学和解剖学检查，包括（a）连续 选择性黄斑区终末和感受野的重建 （B）谷氨酸的变化 黄斑突触的受体基因表达，（c）谷氨酸 受体蛋白在黄斑毛细胞，和（d）在耳锥的变化， 质量，使用扫描EM进行。这些实验的结果 将被纳入发展中的外周前庭模型， 系统

项目成果

The evolution of concepts of vestibular peripheral information processing: toward the dynamic, adaptive, parallel processing macular model

前庭周围信息处理概念的演变：走向动态、自适应、并行处理黄斑模型

• DOI: 10.1080/00016480310000719
• 发表时间: 2003
• 期刊: Acta Oto-Laryngologica
• 影响因子: 1.4
• 作者: M. Ross

Synaptic ribbon plasticity, ribbon size and potential regulatory mechanisms in utricular and saccular maculae.

椭圆囊和囊状黄斑的突触带可塑性、带大小和潜在调节机制。

• 发表时间: 2005
• 期刊: Journal of vestibular research : equilibrium & orientation.
• 作者: Ross,MurielD;Varelas,Joseph
• 通讯作者: Varelas,Joseph