eScent mask for personal protective assurance: a human-centred approach to PPE in the post COVID-19 world

新型冠状病毒引发的恐慌导致全球对口罩的需求增加。与COVID-19相关的创伤导致许多医护人员死亡。最近发表在Cell [1]上的研究表明，SARS-CoV-2感染呼吸道细胞，鼻子是肺部感染开始的主要部位。这为未来的鼻内可穿戴治疗策略开辟了新的方向，可以减少COVID-19和其他冠状病毒在鼻子中的传播。大流行的挑战需要学科之间富有想象力的合作，并可以从提高人群情感和精神健康的创新中受益。eScent正在设计可穿戴的可持续语音激活气味分配的新运动。与IF/Anchored-IN合作，我们正在商业化一种产品，该产品旨在通过舒缓的芳香氛围来使人们平静下来，以增强免疫系统，同时改进FFP 3口罩提供的电流保护。该项目的目的是将当前的eScent分配器（TR 3）用于相关环境中的增强型口罩演示器（TR 6）eScent是一款可穿戴的皮升剂量输送设备，可通过传感器/应用程序/语音识别软件分配任何液体。它建立在20年的传感器诱导气味释放技术和纺织品研究（中央圣马丁/剑桥大学），与飞利浦，北脸的项目，并从谷歌，TransTech实验室的支持。受5项专利保护，eScent将感知人类情感和散发反作用健康芳香相结合，以提高生活质量。我们干预的心理效果应该从根本上减少医疗保健，运输和急救人员的创伤。我们的上市途径是通过GENTEX Europe（NHS/军用PPE供应商），NIHR Brain MIC和剑桥大学临床学院表示了兴趣，认为这是一种减轻危机心理影响的新方法。虽然我们的想法不是一个立即的解决方案，但它与未来的冠状病毒爆发高度相关。如果一种有效的疫苗需要比预期更长的时间，那么它对当前的大流行也是有效的。分配器将提供化妆品批准的液体（带有皮肤/眼睛的安全数据）从护士/接待员/公交车司机或军人佩戴的面罩/遮阳板内部作为威慑/预防“云”来遏制病毒的传播并减少创伤。我们的技术建立并保持了可检测气味水平的局部“球体”。根据用户上下文和/或从语音敏感的可穿戴液体分配器分配的环境，可以使用喷雾剂（和其他喷雾剂）。未来的迭代将使用面具数据、机器学习技术来个性化治疗和护理，这样一旦人工智能系统检测到压力增加（使用语音分析）或环境变化，就可以提供基于证据的抗病毒药物/香味。气味传递是由智能手表中佩戴的生物识别传感器的生命体征（例如温度、心率变异性、语音特征/命令、位置、医院/商店、公共交通工具中的上下文数据）触发的，并包含在由生物可堆肥/可再填充胶囊组成的“消耗品”中（循环经济）。没有实时分配化合物以预防COVID-19的口罩。[1].Hou等人，SARS-CoV-2反向遗传学揭示呼吸道可变感染梯度_，Cell 182，1--18，2020年7月

The panic around coronavirus has resulted in global demand for masks.The trauma associated with COVID-19 has led to the deaths of many healthcare staff. Recent research published in Cell \[1\] suggests that SARs-CoV-2 infects cells of the respiratory tract with the nose being the dominant site from which lung infections begin. This opens new directions for future intranasal wearable therapeutic strategies that could reduce transmission of COVID-19 and other coronaviruses in the nose.The challenge of the pandemic requires imaginative collaborations between disciplines and could benefit from an innovation that enhances the emotional and mental wellbeing of the population.eScent is engineering a new movement in wearable, sustainable voice-activated scent dispensing. In partnership with IF/Anchored-IN, we are commercializing a product that seeks to calm people with a soothing aromatic atmosphere to boost the immune system, whilst improving on current protection provided by FFP3 masks.The aim of this project is to take the current eScent dispenser (TR3) to an enhanced- mask demonstrator in relevant environments (TR6) so that it emits a safe and effective aroma whilst blocking SAR receptors as a novel answer to PPE for frontline workers.eScent is a wearable pico-litre dosed delivery device that dispenses any liquid via sensors/app/voice-recognition software. It builds on 20 years of sensor-induced scent-release technology and textile research (Central Saint Martins/Cambridge University), projects with Philips, North Face, and support from Google, TransTech Labs. Protected by 5 patents, eScent unites sensing human emotion and dispensing counter-active wellbeing aromas to improve quality of life.The psychological effect of our intervention should radically reduce the trauma of healthcare, transport, and emergency workers. Our route to market is via GENTEX Europe (NHS/Military PPE supplier), with interest expressed by the NIHR Brain MIC, and University of Cambridge Clinical School as a novel way to mitigate the psychological impact of the crisis. Although our idea is not an immediate solution, it is highly relevant for future coronavirus outbreaks. If an effective vaccine takes longer than expected, it is also valid for the current pandemic. The dispenser would deliver a cosmetically approved liquid (with safety data for skin/eyes) from inside a facemask/visor that nurses/receptionists/bus drivers or military wear as a deterrent/prevention "cloud" to curb the spread of viruses and reduce trauma.Our technology establishes and maintains a localized "sphere" of detectible levels of scent (and other sprays) dependent upon user-context and/or the environment dispensed from a voice-sensitive wearable liquid dispenser. Future iterations will use mask data, ML technology to personalize treatment and care such that evidenced-based antivirals/aromas can be delivered once an AI system has detected an increase in stress (using voice analytics) or environmental changes. Scent delivery is triggered by vital signs from worn biometric sensors in a smartwatch (e.g. temperature, HRV, speech characteristics/commands, location, contextual data in hospitals/shops, public transport) and contained in "consumables" consisting of bio-compostable/refillable capsules (circular economy).There is no mask that dispenses compounds in real-time to prevent COVID-19\.\[1\].Hou et al.,_SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract_,Cell 182,1--18,July,2020