GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
基本信息
- 批准号:2734106
- 负责人:
- 金额:$ 12.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1990
- 资助国家:美国
- 起止时间:1990-08-10 至 2001-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION: (Adapted from investigator's abstract) Radiation therapy is a
major modality in the treatment of cancer. However, as the application and
efficacy of this treatment has increased, so has the concern for normal
tissue toxicity. For the treatment of abdominal and pelvic tumors,
intestinal tolerance is often a major limiting factor. Studies from the
applicants' lab and other laboratories have demonstrated dramatic changes in
small intestinal and colonic motor activity following fractionated or single
sub-lethal doses of ionizing radiation. Many of these changes have direct
symptomatic relevance to patients receiving radiation therapy and are
responsible for emesis, gastrointestinal cramping and explosive diarrhea.
The applicants have correlated improvements in the contractile changes with
pharmacologic interventions which improve patient tolerance. They now
propose to continue the efforts, focusing on the mechanisms responsible for
the changes they have observed. The primary objectives of this research
proposal are 1) to explore the role of central and peripheral neurokinin 1
receptors in the contractile changes produced by irradiation, 2) to
understand the mechanisms of the coordination between the small intestinal
and colonic contractions induced by irradiation and 3) to define the role of
the putative inhibitory neurotransmitter, nitric oxide, in the radiation
induced contractions.
In a canine model, contractile recordings will be made using strain gauges.
They will be implanted in the animals using sterile surgical techniques.
Antagonists of neurokinin 1 receptor or nitric oxide synthase inhibitors
will be administered either intravenously, intracerebroventricularly or
using close intraarterial techniques in conscious and neurologically intact
animals. More detailed investigations will be performed in a rodent model
and the results correlated with the clinically relevant model of motility
changes.
The ultimate aim is to delineate the mechanisms that produce abnormal motor
patterns during radiation therapy in humans. With this understanding, the
applicants will be able to propose appropriate pharmacologic agents to block
these gastrointestinal effects and improve human tolerance to radiation
exposure.
描述:(改编自研究者摘要)放射治疗是一种
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARY F. OTTERSON其他文献
MARY F. OTTERSON的其他文献
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{{ truncateString('MARY F. OTTERSON', 18)}}的其他基金
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
2142767 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
3464284 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
3464285 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
6177081 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
3464286 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
2905425 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
2394426 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
- 批准号:
3464283 - 财政年份:1990
- 资助金额:
$ 12.66万 - 项目类别:
Post-irradiation modulation of Gastrointestinal (GI) injury
胃肠道 (GI) 损伤的辐射后调节
- 批准号:
7483651 - 财政年份:
- 资助金额:
$ 12.66万 - 项目类别:
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