GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION

电离辐射对胃肠运动的影响

基本信息

  • 批准号:
    2734106
  • 负责人:
  • 金额:
    $ 12.66万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1990
  • 资助国家:
    美国
  • 起止时间:
    1990-08-10 至 2001-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: (Adapted from investigator's abstract) Radiation therapy is a major modality in the treatment of cancer. However, as the application and efficacy of this treatment has increased, so has the concern for normal tissue toxicity. For the treatment of abdominal and pelvic tumors, intestinal tolerance is often a major limiting factor. Studies from the applicants' lab and other laboratories have demonstrated dramatic changes in small intestinal and colonic motor activity following fractionated or single sub-lethal doses of ionizing radiation. Many of these changes have direct symptomatic relevance to patients receiving radiation therapy and are responsible for emesis, gastrointestinal cramping and explosive diarrhea. The applicants have correlated improvements in the contractile changes with pharmacologic interventions which improve patient tolerance. They now propose to continue the efforts, focusing on the mechanisms responsible for the changes they have observed. The primary objectives of this research proposal are 1) to explore the role of central and peripheral neurokinin 1 receptors in the contractile changes produced by irradiation, 2) to understand the mechanisms of the coordination between the small intestinal and colonic contractions induced by irradiation and 3) to define the role of the putative inhibitory neurotransmitter, nitric oxide, in the radiation induced contractions. In a canine model, contractile recordings will be made using strain gauges. They will be implanted in the animals using sterile surgical techniques. Antagonists of neurokinin 1 receptor or nitric oxide synthase inhibitors will be administered either intravenously, intracerebroventricularly or using close intraarterial techniques in conscious and neurologically intact animals. More detailed investigations will be performed in a rodent model and the results correlated with the clinically relevant model of motility changes. The ultimate aim is to delineate the mechanisms that produce abnormal motor patterns during radiation therapy in humans. With this understanding, the applicants will be able to propose appropriate pharmacologic agents to block these gastrointestinal effects and improve human tolerance to radiation exposure.
描述:(改编自研究者摘要)放射治疗是一种

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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MARY F. OTTERSON其他文献

MARY F. OTTERSON的其他文献

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{{ truncateString('MARY F. OTTERSON', 18)}}的其他基金

Post-irradiation modulation of GI injury
胃肠道损伤的辐射后调节
  • 批准号:
    7055643
  • 财政年份:
    2005
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    2142767
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    3464284
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    3464285
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    6177081
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    3464286
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    2905425
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTINAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    2394426
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
GASTROINTESTIONAL MOTOR EFFECTS OF IONIZING RADIATION
电离辐射对胃肠运动的影响
  • 批准号:
    3464283
  • 财政年份:
    1990
  • 资助金额:
    $ 12.66万
  • 项目类别:
Post-irradiation modulation of Gastrointestinal (GI) injury
胃肠道 (GI) 损伤的辐射后调节
  • 批准号:
    7483651
  • 财政年份:
  • 资助金额:
    $ 12.66万
  • 项目类别:

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