GORDON CONFERENCE--MUSCLE CONTRACTILE PROTEINS

要求部分支持1999年戈登研究会议肌肉：收缩蛋白，汇集生物物理学家，生物化学家，细胞生物学家和生理学家来解决收缩机制及其调控。虽然肌动蛋白-肌球蛋白收缩系统的研究最为广泛，但现在人们已经认识到，基于肌动蛋白的系统在从细胞器运输到细胞分裂的许多细胞活动中都起着重要作用。会议的总体重点将是肌肉收缩及其调控的分子基础。有两个主要目的。一个是讨论该领域的重要最新进展，从新确定的分子结构到溶液和纤维中的单分子研究，因为它们涉及收缩机制。此外，还将介绍可能应用于肌肉收缩分析的新方法。在过去的十年中，肌动蛋白和肌凝蛋白的原子分辨率结构的可用性，研究单分子的技术，改进的EM成像方法，以及研究基因修饰分子的机会，已经彻底改变了收缩过程的研究。这些问题，模型和潜在的假设，早于这些新的发展。会议的第二个目标是根据讨论型研讨会的最新成果，集中讨论主要问题、模型和有争议的问题。戈登会议的规模（最多150名与会者）是理想的。将有九次会议。在8月，将有少量正式的介绍，随后将举行一次讨论讲习班，讨论与会议有关的关键问题。讨论将由会议主席和会议海报主席领导，他们将共同负责将海报参与者纳入讨论。在第九届，也是最后一次会议上，杰出的与会者将总结会议的部分内容，以说明该领域已经取得的成就和下一个千年可能取得的成就。

Partial support is requested for the 1999 Gordon Research Conference Muscle: Contractile Proteins to bring together biophysicists, biochemists, cell biologists and physiologists to address the mechanism of contraction and its regulation. While the actin-myosin contractile system has even the most extensively studied, it is now well recognized that acto-mosin based systems have fundamental roles in many cellular activities ranging from organelle transport to cell division. The overall focus of the conference will be the Molecular basis of Muscle Contraction and its Regulation. There are two major aims. One is to discuss important recent developments in the field ranging from newly determined molecular structures to single molecule studies in solution and in fibers as they relate to the contractile mechanism. In addition, new methods that may be applied to analysis of muscle contraction will be introduced. In the past decade the availability of atomic resolution structures for actin and myosin, techniques for studying single molecules, improved EM imaging methods, and the opportunity to study genetically-modified molecules have revolutionized the stud of the contractile process The questions, models, and underlying assumptions, predate these newer developments. The second aim of the conference is to focus on the major questions , models and controversial issues in light of recent results in discussion-based workshops. The size of the Gordon Conference (a maximum of 150 participants) is ideal. There will be nine sessions. In eight, there will be a small number of formal presentations followed by a discussion workshop on critical issues relating to the session. The discussions will be led by the Session Chair and a Session Poster Chair who will together be responsible for incorporating the posters participants into the discussion. In the ninth, and last, session prominent participants will summarize sections of the conference in relation to where the field has been and may go in the next millennium.