OXIDATIVE/ENERGY METAB IN NEURODEGENERATIVE DISORDERS

神经退行性疾病中的氧化/能量代谢分析

• 批准号: 2739667
• 负责人: JOHN P BLASS
• 金额: $ 3.19万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2739667
• 关键词: bioenergetics; meeting /conference /symposium; neural degeneration; oxidative stress; travel

In March of 1999, the New York Academy of Sciences is sponsoring a conference entitled Oxidative/Energy Metabolism in Neurodegenerative Disorders. The conference is expected to take place at The Rockefeller University in New York City. The Principle Investigator and chair is John P. Blass, M.D., Ph.D. The conference cochair is Fletcher H. McDowell, M.D. The purpose of the conference is to bring together basic and clinical investigators studying oxidative/energy metabolism in neurodegenerative diseases. This conference will emphasize disorders where there is evidence of genetically determined or other discrete abnormalities in oxidative/energy metabolism rather than conditions in which energy metabolism is impaired secondary to major insults to the brain such as stroke or trauma. Focusing on disorders in which relatively discrete, molecular genetic abnormalities occur will facilitate a focused and penetrating examination of the fundamental mechanisms involved. The conference will emphasize, but not be limited to, conditions which affect mitochondria, the subcellular organelles which are the major sites of production of energy and free radicals (ROS) in mammalian cells. This meeting will bring together basic scientists who are studying energy metabolism and the generation of ROS at a fundamental level and clinical investigators who are examining disordered oxidative/energy metabolism in neurodegenerative diseases. The interdisciplinary interaction of these groups of investigators will alert the basic scientists to the clinical implications of their studies and the clinical investigators to the need to study energy metabolism in neurodegenerative disease at a mechanistic level. The meeting will lead to transpolination of ideas among the basic and clinical investigators and help to close the gap between basic and applied biology and neurobiology. The proceedings of the conference will be published as a volume of the Annals of the New York Academy of Sciences will be distributed internationally. This volume will be valuable to investigators entering this rapidly expanding field, and in particular will indicate to younger clinical investigators the need to ask mechanistic questions about these disorders.

1999年3月，纽约科学院赞助了一个 神经退行性疾病中的氧化/能量代谢 精神失常。 会议预计将在洛克菲勒举行。 纽约市的一所大学。 首席研究员和主席是 约翰·P·布拉斯，医学博士，博士会议联合主席是弗莱彻H。 McDowell，医学博士 会议的目的是汇集基本的 和临床研究人员研究氧化/能量代谢， 神经退行性疾病 这次会议将强调有证据表明 遗传决定或其他离散异常， 氧化/能量代谢，而不是能量 代谢受损继发于对大脑的主要损害， 中风或外伤 专注于相对离散的疾病， 分子遗传异常的发生将有助于集中和 深入研究所涉及的基本机制。 的 会议将强调，但不限于， 影响线粒体，亚细胞器是主要的 哺乳动物体内产生能量和自由基的部位 细胞 这次会议将汇集基础科学家谁是研究 能量代谢和ROS的产生在一个基本的水平， 正在检查紊乱的氧化/能量的临床研究者 神经退行性疾病的代谢。 跨学科 这些研究人员小组的互动将提醒基本的 科学家们对他们的研究的临床意义和 临床研究人员需要研究能量代谢， 神经退行性疾病的机制。 会议将导致 基础和临床研究者之间的思想转换 帮助缩小基础生物学和应用生物学之间的差距， 神经生物学会议记录将作为 《纽约科学院年鉴》将于 分布在国际上。 这本书将是宝贵的， 进入这一迅速发展的领域的研究人员，特别是 将向年轻的临床研究者表明， 关于这些疾病的机械问题。