INNATE IMMUNITY

先天免疫

• 批准号: 2821500
• 负责人: ALAN R. FLEISCHMAN
• 金额: $ 0.1万
• 依托单位: NEW YORK ACADEMY OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2821500
• 关键词: immunology; meeting /conference /symposium; travel

The New York Academy of Medicine has been dedicated for over 150 years to enhancing the health of public through education, research and advocacy. Each year the Academy sponsors a Basic Science Symposium which explores a developing field in a comprehensive manner. This approach is chosen to allow maximal interaction among researchers and to enhance the creativity of the field by identify new problems to be addressed and new approaches to seeking answers to the problems. Among mammalian immunologists, there has been a recent shift in paradigms accompanying the recognition that much of the specificity of the immune response for pathogens is guided by innate immune response recognition mechanisms. At the same time, recent molecular evidence suggests that innate immune response mechanisms are conserved in evolution. As a result, it seems that genetic experiments that can be conducted in lower organisms are likely to provide new insights into mammalian immune responses. This meeting represents the first attempt to bring together scientists from the very different backgrounds of mammalian immunobiology, Drosophila genetics, and plant disease resistance to discuss this emerging field. This one and one-half day symposium to be held on December 7-8, 1998: "Innate Immunity: Ancient Signals, Modern Implications" seeks to bring scientists from complementary backgrounds together to address this new field before an audience of scientists and clinicians with interest in basic immunology. Topics to be presented include: Mammalian Innate Immune Responses, Links Between Innate and Adaptive Immunity, Innate Immunity and the Recognition of Danger, Insect and Plant Immune Responses, Rel Proteins and the Diversity of Innate Immune Responses.

纽约医学院150多年来一直致力于 通过教育、研究和宣传提高公众健康水平。 每年该学院赞助一个基础科学研讨会，探讨 全面发展领域。选择这种方法是为了 允许研究人员之间进行最大限度的互动，并提高创造力 通过确定需要解决的新问题和新方法， 去寻找问题的答案。 在哺乳动物免疫学家中， 伴随着免疫系统的许多特异性 对病原体的应答由先天免疫应答识别引导 机制等与此同时，最近的分子证据表明， 先天免疫应答机制在进化中是保守的。因此，在本发明中， 似乎可以在低等生物中进行的遗传实验 很可能为哺乳动物的免疫反应提供新的见解。这 这次会议是第一次尝试将来自世界各地的科学家聚集在一起， 哺乳动物免疫生物学的不同背景，果蝇 遗传学和植物抗病性来讨论这一新兴领域。 这次为期一天半的研讨会将于1998年12月7日至8日举行： “先天免疫：古老的信号，现代的含义”试图带来 来自互补背景的科学家一起解决这个新的问题， 在科学家和临床医生的观众面前， 基础免疫学主题包括：哺乳动物先天免疫 反应，先天免疫和适应性免疫之间的联系，先天免疫和 危险识别，昆虫和植物免疫反应，Rel蛋白 和先天免疫反应的多样性。

项目成果

Relaxed repression of herpes simplex virus type 1 genomes in Murine trigeminal neurons.

小鼠三叉神经元中 1 型单纯疱疹病毒基因组的放松抑制。

• DOI: 10.1128/jvi.01068-07
• 发表时间: 2007
• 期刊: Journal of virology
• 影响因子: 5.4
• 作者: Terry-Allison,Tracy;Smith,ColtonA;DeLuca,NealA
• 通讯作者: DeLuca,NealA