EMOTION AND MOOD DISORDERS--ERP/EEG

情绪和心境障碍--ERP/EEG

• 批准号: 2891085
• 负责人: Ralf Jürgen Kayser
• 金额: $ 7.42万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2891085
• 关键词: brain electrical activity; cerebral dominance; clinical research; depression; electroencephalography; emotions; evoked potentials; galvanic skin response; human subject; major depression; mood disorders; neural information processing; psychophysiology; visual stimulus

DESCRIPTION (Adapted from applicant's abstract): The relationship between measures of cortical activity and autonomic measures of emotional arousal has not been adequately studied in mood disorders, and yet, this may be of critical importance for understanding findings of regional hemispheric activation in these disorders. The proposal uses a unique set of picture stimuli to investigate autonomic and central nervous system asymmetries during emotional processing in depressed patients and healthy controls. Bilateral electrodermal activity (EDA), electroencephalographic (EEG), and event-related potential (ERP) measures are recorded simultaneously, i.e., from the left and right hand from homologous sites over the left and right hemisphere. Emotionally arousing and matched neutral stimuli are used to study effects on these peripheral and central indicators of electrophysiological activity in 50 depressed patients and 50 healthy controls. Pictures of patients with dermatological diseases, one half before cosmetic surgery (negative) and one half after successful treatment (neutral), serve as stimuli differing primarily in emotional content. These stimuli will be briefly exposed to the left or right visual field, in order to stimulate each hemisphere separately. An important aim is to examine the relationship between autonomic and central measures of emotional reactivity in depressed patients as well as in healthy subjects in one paradigm. The study explores specific cortical regions that will display EEG/ERP asymmetries related to EDA asymmetries. The recordings of 30 channels of EEG will allow the use of current-source density techniques for topographic analysis of regional cortical activity. Symptom features of depression are also an important aspect of the study, with particular emphasis given to the relation of EDA, EEG, and ERP measures to symptoms related to emotional responsivity, in particular anhedonia. On a theoretical level, the investigators hypothesize advantage for processing emotional stimuli and a general reduction in electrodermal activity. A long-range clinical goal is to contribute toward the development of objective measures for assessing cortical and autonomic reactivity to emotional stimuli in depression.

描述（改编自申请人摘要）： 皮质活动的测量和情绪唤起的自主测量 在情绪障碍中还没有得到充分的研究，然而，这可能是 对于了解区域半球的发现至关重要 在这些疾病中激活。 该提案使用了一组独特的图片 研究自主神经和中枢神经系统不对称的刺激 在抑郁症患者和健康对照组的情绪处理过程中。 双侧皮电活动（EDA）、脑电图（EEG）和 同时记录事件相关电位（ERP）测量，即， 从左边和右边的同源位点 半球 激发性和匹配的中性刺激用于 研究对这些外周和中枢指标的影响， 50例抑郁症患者和50例健康人的电生理活动 对照 皮肤病患者的照片，一半 整容手术前（阴性）和成功治疗后的一半 （中性），作为主要在情感内容上不同的刺激。 这些 刺激将短暂地暴露于左或右视野， 分别刺激每个半球 一个重要的目的是审查 情绪反应自主神经和中枢神经测量之间的关系 在抑郁症患者和健康受试者中的一个范例中。 的 研究探索了将显示EEG/ERP的特定皮层区域 与EDA不对称有关的不对称。 30个频道的录音 EEG将允许使用电流源密度技术进行地形图检查。 区域皮质活动分析 抑郁症的症状特征是 这也是研究的一个重要方面，特别强调 EDA，EEG和ERP测量与情绪相关症状的关系 特别是快感缺乏症 在理论层面上， 研究人员假设处理情绪刺激的优势， 皮肤电活动普遍减少。 长期临床目标是 为制定客观的评估措施做出贡献 抑郁症患者对情绪刺激的皮层和自主神经反应。