课题基金 / 基金详情

MOLECULAR REGULATION OF FOLATE AND ANTIFOLATE TRANSPORT

MOLECULAR REGULATION OF FOLATE AND ANTIFOLATE TRANSPORT
叶酸和抗叶酸转运的分子调节
批准号：
2654068
负责人：
Larry H Matherly
金额：
$22.25万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-02-12 至 1999-01-31
来源：
https://reporter.nih.gov/project-details/2654068
关键词：
CHO cells Sf9 cell line antiserum binding proteins complementary DNA crosslink drug resistance folate genetic library genetic mapping genetic promoter element glycoproteins human genetic material tag intermolecular interaction membrane proteins messenger RNA neoplastic cell polymerase chain reaction protein purification protein structure function site directed mutagenesis southern blotting transfection transport proteins vitamin antagonist

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中文摘要
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英文摘要
DESCRIPTION: The goal of this project is to characterize the structure and function of the human "classical" reduced folate carrier (RFC). Human cDNAs isolated in the applicant's laboratory restore MTX sensitivity and RFC activity in transport-defective Chinese hamster ovary cells. Studies are proposed to use anti-RFC antisera to examine structural and functional relationships between other folate transport proteins and the RFC, clone the gene for the RFC and map the intron/exon boundaries and promoter region and identify the structural and functional domains of the human RFC.
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