APPLICATION OF SILICON ELECTRODES IN NON NEURAL & IN VITRO PREPARATIONS

硅电极在非神经元中的应用

• 批准号: 6122988
• 负责人: WAYNE CASCIO
• 金额: --
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-15 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6122988
• 关键词: Mammalia; bioengineering /biomedical engineering; biomedical equipment development; biomedical resource; cardiovascular system; eye; human tissue; prosthesis; technology /technique

In addition to the classic probe application areas of cortical, deep structures, peripheral nerve and neural prostheses, there is also interest in using the probes to record from other areas including cardiac muscle and tissue slices. Cardiac muscle, as with peripheral nerve, is a challenging preparation for silicon probes in that penetration is difficult and the relative movement of the structure is very large. Dr. Cascio, in collaboration with Dr. Nagle, has been successful in recording longitudinal activation in an ischemic rabbit papillary muscle. This group has also presented data on activation of the iridium sites to reduce impedances to levels suitable for their recordings. Investigators from several disciplines have been pursuing methods to use probes for recording from tissue slices, including retina and salamandar olfactory bulb.

除了皮质的经典探头应用领域外， 深部结构、周围神经和神经假体， 感兴趣的是使用探头记录其他领域，包括 心肌和组织切片。 心肌，如外周 神经，是一个具有挑战性的准备硅探针， 穿透是困难的，结构的相对运动是 非常大。 Cascio博士与Nagle博士合作， 成功记录了缺血家兔的纵向激动 乳头肌 该小组还提供了关于激活 铱位点以将阻抗降低到适合于其 录音. 来自多个学科的调查人员一直在寻找 使用探针记录组织切片的方法，包括 视网膜和蝾螈嗅球。