EFFECT OF VOLATILE ANESTHETICS ON CA2+ ATPASE

挥发性麻醉剂对 CA2 ATP酶的影响

• 批准号: 6282904
• 负责人: DANUTA KOSK-KOSICKA
• 金额: $ 1.7万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-04-01 至 1999-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6282904
• 关键词: anesthesiology; biological products; biomedical resource; human tissue; spectrometry

Anesthetics have been in clinical use for nearly 100 years, but their mechanism of action is still unknown. Effect of anesthetics such as alcohols, barbiturate on fluorescence intensity decay of multitryptophan protein PM ATPase of has been studied. Time-resolved fluorescence confirms the diffusional character of the fluorescence quenching. Quenching is most effective on surface exposed tryptophans. Information on the effects of anesthetics on membrane-bound proteins may provide insights into the mechanism of action.

麻醉剂在临床上已经使用了近100年，但 它们的作用机制仍然未知。 麻醉药的作用 如醇类、巴比妥类对荧光强度衰减的影响 多色氨酸蛋白PM ATP酶进行了研究。 时间分辨 荧光证实了荧光的扩散特性 淬火 淬火对暴露的表面最有效 是的 关于麻醉剂对 膜结合蛋白质可以提供深入了解的机制， 行动上