REGULATION OF THE FSH RECEPTOR IN SERTOLI CELLS
REGULATION OF THE FSH RECEPTOR IN SERTOLI CELLS
批准号:
2773492
负责人:
MELISSA A DAGGETT
金额:
$3.67万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
未结题
起止时间:
1999-07-31 至
中文摘要
哺乳动物的繁殖成功取决于垂体-性腺
英文摘要
Reproductive success in mammals is dependent on the pituitary-gonadal
reproductive axis. Follicle-stimulating hormone (FSH) is a critical
component of the reproductive axis. This hormone has important effects
on both the development and differentiation of the testis. FSH elicits
its biological effects through the FSH receptor (FSHR), which is
expressed exclusively in Sertoli cells in the testis and granulosa cells
in the ovary. The cell-specific expression of the FSHR suggests that
mechanisms specific to the gonads are involved in its transcriptional
activation. We hypothesize that the mechanism regulating FSHR gene
expression in Sertoli cells will involve a unique set of transcription
factors binding to the promoter region of the FSHR gene. The unique
nature of FSHR expression in Sertoli cells, suggest these factors may
be globally important for a host of transcriptional events occurring
during gene activation in Sertoli cells. The specific aims in this
proposal are designed to identify important control regions of the FSHR
gene in vivo by in vivo genomic footprinting using ligation-mediated
(LM)-PCR and to identify and characterize the protein(s) that bind an
important FSHR promoter element, the E-box, using DNA oligonucleotide
affinity chromatography.
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国内基金
海外基金
MTA2在睾丸支持细胞(Sertoli cells)中的功能和机制研究
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批准号:31271248
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项目类别:面上项目
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资助金额:80.0万元
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批准年份:2012
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负责人:李伟
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依托单位: