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NOVEL CYCLIC-PEPTIDE-BASED ANTIMITOTICS

NOVEL CYCLIC-PEPTIDE-BASED ANTIMITOTICS
新型环肽抗有丝分裂剂
批准号：
2862902
负责人：
Robert SCOTT LOKEY
金额：
$3.17万
依托单位：
HARVARD MEDICAL SCHOOL
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
未结题
起止时间：
1999-07-01 至
来源：
https://reporter.nih.gov/project-details/2862902
关键词：
antimitotics chemical structure function cyclic peptides cyclins cytotoxicity membrane permeability peptide chemical synthesis peptide library

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We will synthesize a small library of heptapeptide scaffolds to explore the effects of scaffold conformation on cyclization and cell permeability. We will select several novel cell-permeable cyclic scaffolds for elaboration into libraries of potential protein ligands and screen them for effects on the cell cycle in a number of different assays. Several active compounds will be chosen for further study. We are particularly interested in compounds that arrest cells in mitosis by directly perturbing the degradation of cyclin B or by targeting components of the mitotic spindle and thus triggering the mitotic checkpoint pathway.
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Advancing the basic science of membrane permeability in macrocyclic peptides
Upgrade of core imaging instrumentation and robotics for the UCSC Chemical Screening Center
Cyclic peptide permeability
Cyclic peptide permeability
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