PHYSIOLOGIC STUDIES OF ANGER IN DEPRESSED PATIENTS

抑郁症患者愤怒的生理学研究

• 批准号: 2884951
• 负责人: DARIN D DOUGHERTY
• 金额: $ 15.16万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2884951
• 关键词: angers; behavioral /social science research tag; bioimaging /biomedical imaging; brain mapping; clinical research; electromyography; galvanic skin response; grief; heart rate; human subject; ligands; limbic system; major depression; mental disorder diagnosis; neural information processing; neurochemistry; neuropathology; positron emission tomography; psychometrics; psychophysiology; receptor binding; sensory receptors; serotonin receptor

This is an application for an NIMH Mentored Patient-Oriented Research Career Development Award (K23) titled "Physiologic Studies of Anger in Depressed Patients". It allows the candidate, who has experience with clinical psychopharmacology and positron emission tomography (PET) activation studies, to gain expertise in psychophysiology and in vivo neuroreceptor imaging techniques in the study of affective dysregulation in major depressive disorder (MDD). Numerous PET studies have demonstrated abnormal metabolic patterns in anterior paralimbic structures in patients with MDD. Numerous PET studies following negative emotion induction paradigms in healthy controls have demonstrated that anterior paralimbic structures are involved in the processing of negative emotions such as sadness and disgust. Few studies have utilized these paradigms to study emotional processing in subjects with MDD, a disorder characterized by profound disturbances of affect regulation. Patients with a well-characterized subtype of MDD, MDD with anger attacks, present with sudden uncharacteristic spells of anger accompanied by autonomic activation. This subtype of MDD provides an opportunity to characterize affect dysregulation of a specific type (anger) in a well-defined clinical population, ultimately helping to elucidate the pathophysiology of MDD. We propose to study three populations: MDD with anger attacks, MDD without anger attacks, and healthy control subjects. We will utilize narrative scripts to induce emotional states (angry, sad, and neutral states) and assess physiologic responses in the study populations utilizing psychophysiologic measures, PET activation studies, and PET in vivo neuroreceptor imaging techniques. By this proposal, the candidate seeks training in (1) clinical studies of MDD, (2) affective neuroscience, (3) statistics relevant to functional neuroimaging, and (4) neuroreceptor imaging with PET. This rigorous training plan, integrating strong didactics and multidisciplinary expertise, will teach the candidate how to synthesize information from diverse fields in studying affect dysregulation in MDD. This integrated program of training and research will advance our knowledge of the pathophysiology of MDD, yield new tools for studying emotional processing, and give the candidate the skills needed to achieve independence in a highly complex field.

这是NIMH指导的以患者为导向的研究职业发展奖（K23）的申请，题为“抑郁患者愤怒的生理学研究”。 它允许候选人，谁拥有临床精神药理学和正电子发射断层扫描（PET）激活研究的经验，以获得心理生理学和体内神经受体成像技术在重度抑郁症（MDD）的情感失调的研究专业知识。 许多PET研究已经证实了MDD患者的前边缘结构的异常代谢模式。 在健康对照组中进行的许多负性情绪诱导范式的PET研究表明，前边缘结构参与了悲伤和厌恶等负性情绪的处理。很少有研究利用这些范式来研究MDD受试者的情绪处理，MDD是一种以情感调节严重紊乱为特征的疾病。 MDD的一个明确的亚型，即伴有愤怒发作的MDD患者，表现为突然的不典型的愤怒发作，伴有自主神经激活。 MDD的这种亚型提供了一个机会，在明确定义的临床人群中表征特定类型（愤怒）的情感失调，最终有助于阐明MDD的病理生理学。 我们建议研究三个人群：MDD与愤怒的攻击，MDD没有愤怒的攻击，和健康的控制对象。 我们将利用叙事脚本诱导情绪状态（愤怒、悲伤和中性状态），并利用心理生理学测量、PET激活研究和PET体内神经受体成像技术评估研究人群的生理反应。通过这个提议，候选人寻求以下方面的培训：（1）MDD的临床研究，（2）情感神经科学，（3）与功能性神经成像相关的统计学，以及（4）PET神经受体成像。 这个严格的培训计划，整合了强大的教学和多学科专业知识，将教候选人如何综合来自不同领域的信息，研究MDD中的情感失调。 这种培训和研究的综合计划将推进我们对MDD病理生理学的了解，为研究情绪处理提供新的工具，并为候选人提供在高度复杂的领域实现独立所需的技能。