NEURAL CIRCUITRY AND COGNITIVE FUNCTION IN SCHIZOPHRENIA

虽然精神分裂症的诊断是基于它的现象学 症状和纵向病程，几乎所有精神分裂症患者 表现出明显的认知功能障碍。两国之间的关系 认知功能障碍与神经解剖功能障碍及症状 精神分裂症是不被理解的。最新开发的模型 人类与非人类脑功能与认知功能的关系 灵长类动物表明，即使是最基本的认知功能也是通过中介实现的 通过复杂的神经电路。这些模式的出现，加上 神经解剖学定位模型无法解释症状 精神分裂症患者的认知缺陷和症状 精神分裂症可以通过神经回路功能障碍来解释。 这些病人。项目1将解决认知和认知之间的关系 精神分裂症AS患者神经解剖激活的缺陷和模式 由正电子发射计算机断层扫描(PET)评估。项目2将包括测试神经电路的模型 用验证性路径分析PET数据对精神分裂症患者功能障碍的影响 分析。这些项目将通过以下实验室工作提供信息 人类神经组织的连通性，特别是神经回路 前额叶皮质与丘脑和海马体之间的联系 尾状核、内嗅皮层和海马旁回。决赛 拟议研究计划的阶段将建立在获得的技能的基础上，如 职业发展计划的一部分，侧重于基础神经科学和 神经网络建模。

Although schizophrenia is diagnosed on the basis of its phenomenological symptoms and longitudinal course, almost all schizophrenic patients demonstrate significant cognitive dysfunction. The relationship between cognitive deficits and the neuroanatomic dysfunction and symptoms of schizophrenia is not understood. Recently developed models of the relationship between brain function and cognition in human and nonhuman primates suggest that even the most basic cognitive functions are mediated by complex neural circuitry. The advent of these models, coupled with the inability of neuroanatomic localization models to account for the symptoms of schizophrenia, suggest that the cognitive deficits and symptoms of schizophrenia may be explained by dysfunctions in the neural circuitry of these patients. Project 1 will address the relationship between cognitive deficits and patterns of neuroanatomic activation in schizophrenia as assessed by PET. Project 2 will involve testing models of neural circuitry dysfunction in schizophrenia by analyzing PET data with confirmatory path analysis. These projects will be informed by laboratory work on the connectivity of human neural tissue, particularly the neural circuits connecting the prefrontal cortex with the thalamus and the hippocampus via the caudate nucleus, entorhinal cortex and parahippocampal gyrus. The final phase of the proposed research plan will build upon the skills acquired as part of the career development plan focusing on basic neuroscience and neural network modeling.