EIF4E OVEREXPRESSION AND BREAST CANCER RECURRENCE
EIF4E OVEREXPRESSION AND BREAST CANCER RECURRENCE
批准号:
2869821
负责人:
BENJAMIN D LI
金额:
$10.0万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-09-18 至 2000-09-17
中文摘要
研究人员建议测定真核起始因子4E,
英文摘要
The investigators propose to determine eukaryotic initiation factor 4E,
which assists RNA helicases to bind to 51 untranslated regions of mRNA.
Overexpression in cell lines produces a malignant phenotype. In
preliminary studies, overexpression determined by Western blot occurs
in breast cancers, but not in benign breast lesions. Preliminary data
also associates the degree of overexpression with tumor aggressiveness
and survival. However, these preliminary studies are based on small
numbers. Thus, the investigators propose to perform a prospective study
of 168 women with stage II or III breast cancer. Their first aim is to
assess eIF4E overexpression in breast tissue, and their second aim is
to perform ER and PR analysis so as to be able to relate this data to
the eIF4E. They believe that in 5 years, they will have enough
statistical power to determine if overexpression is associated with
recurrence. The investigators believe that this data might lead to more
informed decisions regarding who needs chemotherapy, i.e., by
implication that if eIF4E is predictive of recurrence in stage II, then
it might be for stage I as well. Then, a much larger study with
sufficient power for determining recurrence in stage I breast cancer
will be justified.
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