冠状动脉疾病的基因分析-猫眼课题宝

冠状动脉疾病的基因分析

批准号：

2651508

负责人：

MICHAEL T BOYCE-JACINO

金额：

$31.89万

依托单位：

ORCHID BIOCOMPUTER, INC.

依托单位国家：

美国

项目类别：

财政年份：

1998

资助国家：

美国

项目状态：

已结题

起止时间：

1998-07-01 至 2000-05-31

来源：

https://reporter.nih.gov/project-details/2651508

关键词：

cardiovascular disorder diagnosis coronary artery coronary disorder diagnosis design /evaluation diagnostic tests genetic markers genetic polymorphism genetic susceptibility genotype human genetic material tag

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DESCRIPTION (Adapted from investigator's abstract): The medical and economic impact of coronary artery disease (CAD) is one of the leading causes of death today in the US. A clear need exists for the early identification of individuals at risk for developing premature CAD. In this Phase II proposal the investigators propose to develop a genotyping kit, based on the solid-phase primer extension genotyping technology, which would enable the simultaneous analysis of multiple suspected CAD polymorphisms in a single reliable, informative biochemical format. Development of the Phase II prototype kit will occur in three stages: Aim 1) development of a 20 gene CAD genotyping primer panel for GBA primer extension; Aim 2) development of a glass-slide-based microarray of the Aim 1 primers, reagents, protocols and analysis software; Aim 3) genotyping of a large control and patient population using the kit components developed in Aim 2. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

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