GENETIC ANALYSIS OF CORONARY ARTERY DISEASE

冠状动脉疾病的基因分析

• 批准号: 2651508
• 负责人: MICHAEL T BOYCE-JACINO
• 金额: $ 31.89万
• 依托单位: ORCHID BIOCOMPUTER, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2000-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2651508
• 关键词: cardiovascular disorder diagnosis; coronary artery; coronary disorder; diagnosis design /evaluation; diagnostic tests; genetic markers; genetic polymorphism; genetic susceptibility; genotype; human genetic material tag

DESCRIPTION (Adapted from investigator's abstract): The medical and economic impact of coronary artery disease (CAD) is one of the leading causes of death today in the US. A clear need exists for the early identification of individuals at risk for developing premature CAD. In this Phase II proposal the investigators propose to develop a genotyping kit, based on the solid-phase primer extension genotyping technology, which would enable the simultaneous analysis of multiple suspected CAD polymorphisms in a single reliable, informative biochemical format. Development of the Phase II prototype kit will occur in three stages: Aim 1) development of a 20 gene CAD genotyping primer panel for GBA primer extension; Aim 2) development of a glass-slide-based microarray of the Aim 1 primers, reagents, protocols and analysis software; Aim 3) genotyping of a large control and patient population using the kit components developed in Aim 2. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（改编自研究者摘要）：医学和