VERSATILE SYNTHESIS OF ANNONACEOUS ACETOGENINS

番荔枝内酯是一类发展迅速的天然产物。 具有广泛的生物活性，包括抗肿瘤和 杀虫的承诺。这项建议描述了一种多功能的合成策略 使用催化闭环复分解(RCM)来访问多个 相邻的含有番荔枝内酯的双四氢呋喃。RCM的用法是 扩展到四氢呋喃链段的合成以及 丁烯内酯末端是许多乙酰生素所共有的，以及一个 其他自然和非自然目标的宿主。概述的提案 提出了处理对称双四氢呋喃的替代协议 核心结构以及那些不完全对称的结构。一个完整的 提出了一种模型目标阿西米星的合成方法。

Annonaceous acetogenins are a rapidly growing class of natural products with a vast array of biological activities including anti-tumor and pesticidal promise. This proposal describes a versatile synthetic strategy using catalytic ring closing metathesis (RCM) for accessing several adjacent bis-THF containing Annonaceous acetogenins. The use of RCM is extended to the synthesis of both the tetrahydrofuran segment as well as the butenolide terminus common to many of the acetogenins as well as a host of other natural and unnatural targets. The outlined proposal presents alternative protocols that deal with both symmetrical bis-THF core structures as well as those lacking complete symmetry. A complete proposed synthesis of a model target asimicin is presented.