CALIBRATION AND PRE-CLINICAL TRIALS OF AN OPTICAL DEVICE

光学设备的校准和临床前试验

• 批准号: 6141989
• 负责人: JOSEPH ZEYLIKOVICH
• 金额: $ 10万
• 依托单位: MEDICAL OPTICAL IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2000-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6141989
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; computer assisted diagnosis; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; human subject; image processing; imaging /visualization /scanning; infrared radiation; mammography; optics; phantom model

The strategic goal of Medical Optical Imaging, Inc. is to build and market an Optical Mammography device. The device will serve both screening and diagnostic purposes. The device incorporates two key components as integral parts: hardware and software. These components will work in conjunction with each other. The state-of-the-art hardware unit measures output diffuse light in the frequency domain for many modulated frequencies in the range from 300kHz to 1 GHz for 3 or more wavelengths using near infrared light. The software will use this data as input to reconstruct images of abnormalities in the breast tissues and to provide diagnosis. The software will be based on a fundamentally new mathematical algorithm for image reconstruction, the so called Elliptic System Method (ESM). Through this application the company requests partial support for the test and calibration of these two components on phantom media and, most important pre-clinical trials on several tens of breast volunteers. The remainder of the support will come from private capital raised by the company.The University of North Carolina at Charlotte will be a sub- contractor for this STTR grant to partially support the efforts of professors Michael V. Klibanov and Thomas R. Lucas, who are co-inventors of the Elliptic Systems Method and major stockholders of the company. PROPOSED COMMERCIAL APPLICATIONS: The ultimate aim of this project is to build and market an optical mammography device that could be used as a screening or diagnostic tool for cancer.

Medical Optical Imaging，Inc.的战略目标是制造和销售一种光学乳房X光摄影设备。 该设备将用于筛查和诊断目的。 该设备包括两个关键组成部分：硬件和软件。 这些组成部分将相互配合工作。 最先进的硬件单元使用近红外光测量频域中的输出漫射光，用于300 kHz至1 GHz范围内的许多调制频率和3个或更多波长。 该软件将使用该数据作为输入，以重建乳腺组织中异常的图像并提供诊断。 该软件将基于一种全新的图像重建数学算法，即所谓的椭圆系统方法（ESM）。通过该应用程序，公司要求对这两种组件在体模介质上的测试和校准提供部分支持，以及对数十名乳腺志愿者进行最重要的临床前试验。 其余的支持将来自该公司筹集的私人资本。位于夏洛特的北卡罗来纳州大学将成为这项STTR赠款的分包商，以部分支持迈克尔·V·克里巴诺夫教授和托马斯·R卢卡斯，谁是共同发明人的椭圆系统方法和大股东的公司。拟议的商业应用：该项目的最终目标是建立和销售一种光学乳房X光检查设备，可用作癌症的筛查或诊断工具。