MULTIDIMENSIONAL PHASE VELOCITY MRI

多维相速 MRI

• 批准号: 6281427
• 负责人: TAL GEVA
• 金额: $ 2.01万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281427
• 关键词: aorta; aorta coarctation; blood pressure; cardiovascular disorder diagnosis; clinical research; heart circulation; heart imaging /visualization /scanning; human subject; hypertension; magnetic resonance imaging; medical complication

Systemic hypertension is a common complication years after successful repair of coarctation of the aorta. The study proposes to use multi- dimensional phase velocity magnetic resonance imaging to determine whether abnormal blood flow patterns across the aortic arch and/or abnormal aortic compliance contribute to post-coarctation repair hypertension. The study population will consist of patients with: repaired coarctation normotensive at rest, repaired coarctation hypertensive at rest, and normal controls. The relationships between aortic blood flow and measured parameters will provide insight into possible mechanisms of hypertension after repair of coarctation.

系统性高血压是治疗成功数年后的常见并发症。 主动脉缩窄修补术。这项研究建议使用多个 空间相速度磁共振成像确定 是否存在穿过主动脉弓和/或的异常血流模式 主动脉顺应性异常有助于缩窄后修复 高血压。研究人群将包括患有以下疾病的患者： 修复静息时血压正常的狭窄，修复狭窄 静息时高血压，正常对照组。两国之间的关系 主动脉血流和测量的参数将提供对 狭窄修复后高血压的可能机制。