AGE RELATED CHANGES IN CAMP MEDIATED SYNAPTIC PLASTICITY

营地介导的突触可塑性与年龄相关的变化

• 批准号: 2670346
• 负责人: KAREN D PARFITT
• 金额: $ 8.74万
• 依托单位: POMONA COLLEGE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2670346
• 关键词: aging; behavioral /social science research tag; cyclic AMP; electrostimulus; enzyme activity; enzyme inhibitors; hippocampus; immunocytochemistry; laboratory rat; learning; long term potentiation; neuropharmacology; phosphodiesterases; phosphoprotein phosphatase; phosphorylation; protein kinase

DESCRIPTION This application is based on the finding that beta receptor activation in conjunction with low frequency stimulation induces long term potentiation (called AC-LTP) in young rats but not in aged animals. The findings that aged rats have intact high frequency stimulation induced LTP and reduced short term responses to a beta agonist and forskolin suggest that a site after receptor activation is involved. The goal of this grant is to determine the biochemical defect, to determine if it is pre- or postsynaptic and to correlate changes in AC-LTP with spatial learning.

本申请是基于对β受体的发现 激活与低频刺激相结合可产生长期效应 增强(称为AC-LTP)在年轻大鼠身上，但在老年动物身上不是。这个 老年大鼠完整高频刺激诱导的长时程增强 并降低了对β受体激动剂和Forsklin的短期反应 受体激活后的一个部位参与其中。这笔赠款的目的是 是确定生化缺陷，确定它是前驱还是前驱 并将AC-LTP的变化与空间学习联系起来。