CANCER RISK AND MARIJUANA USE

描述：（申请人的描述）我们提出了试点和发展 使用临床数据研究大麻对健康的影响 使用. 具体来说，我们将评估研究癌症风险的可行性 根据收集到的大麻使用信息， 常规从患者进入罗斯威尔公园癌症研究所（RPCI），因为 1982. 这些数据需要与医疗记录和肿瘤登记匹配 数据、评价答复率和完整性以及 疾病和患者出生队列和性别。 我们将评估 这些数据用于病例对照研究，目的是复制最近的 其他人报告某些患者患某些类型癌症的风险， 以及其他场所是否存在风险。 初始 调查将集中于前列腺癌和子宫颈癌。 后续 研究将检查在其它主要肿瘤类型包括肺， 结肠直肠癌、卵巢癌和乳腺癌。 为了更好地理解 风险因素和暴露在患者的癌症风险，我们将研究 在整个研究人群中暴露变量之间的相关性。 我们还将对数据进行质量控制评估， 通过我们的方法收集的大麻暴露数据的可重复性， 已经就业。 一旦这些发展步骤完成， 分析数据库可用于探索新的假设，验证 其他人的发现，并检查风险的相互作用，迄今为止， 可能 它也有可能成为未来的基础。 将生物和/或分子标记物与 定义的流行病学资源。 由于发展的性质， 活动以及PI和赞助机构的有限优先权 在药物滥用研究的经验，这项申请是根据小 赠款方案。

DESCRIPTION: (Applicant's Description) We propose pilot and developmental studies on the use of clinical data to study the health effects of marijuana use. Specifically, we will assess the feasibility of studying cancer risk based upon information regarding marijuana use that have been collected routinely from patients entering Roswell Park Cancer Institute (RPCI) since 1982. These data require matching to medical record and tumor registry data, evaluation of response rates and completeness, and classification by disease and patient birth cohort and sex. We will evaluate the utility of these data for case-control studies for the purposes of replicating recent reports by others of risk for certain cancer types in certain patients as well as the presence or absence of risk for other sites. Initial investigation will focus on prostate and cervical cancer. Subsequent studies will examine effects in other major tumor types including lung, colorectal, ovary and breast cancers. To better understand the interaction of risk factors and exposures in patients at risk of cancer we will examine correlation among exposure variables across the entire population studied. We also will conduct quality control assessments of the data to determine the reproducibility of marijuana exposure data collected by the means we have employed. Once these developmental steps are accomplished, this analytic database can be used to explore new hypotheses, validate the findings of others, and examine interactions of risks not heretofore possible. It is also possible that it can be the basis for future multidisciplinary efforts that link biological and/or molecular markers to the defined epidemiologic resource. Because of the developmental nature of the activities and the PI and sponsoring institution's limited prior experience in drug abuse research, this application is made under the Small Grants Program.